1. Apoptosis
    MAPK/ERK Pathway
    GPCR/G Protein
    Protein Tyrosine Kinase/RTK
  2. Apoptosis
    Raf
    Ras
    ROS
    MDM-2/p53
  3. Antitumor agent-60

Antitumor agent-60 

Cat. No.: HY-146432
Handling Instructions

Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model.

For research use only. We do not sell to patients.

Antitumor agent-60 Chemical Structure

Antitumor agent-60 Chemical Structure

CAS No. : 865784-65-2

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Description

Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].

IC50 & Target

IC50: 12 nM in A549, 19 nM in OVCaR-3, 29 nM in SGC-7901, 22 nM in HCT-116[1]
Kd: 721.3 nM (CRAF RBD)[1]

Molecular Weight

508.54

Formula

C24H28O10S

CAS No.
SMILES

COC1=CC(OC)=C(C(OC)=C1)/C=C/S(=O)(CC2=CC=C(C(OC(CCCC(O)=O)=O)=C2)OC)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Antitumor agent-60
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