865784-65-2
Chemical Structure
Antitumor agent-60
- CAS No.: 865784-65-2
- Formula:C24H28O10S
- Molecular Weight:508.54
IUPAC Name: (E)-5-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenoxy)-5-oxopentanoic acid
InChIKey: VNTUUFKNTZWWHY-ZHACJKMWSA-N
SMILES: COC1=CC(OC)=C(C(OC)=C1)/C=C/S(=O)(CC2=CC=C(C(OC(CCCC(O)=O)=O)=C2)OC)=O
Biological Activity: Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].
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Antitumor agent-60 | Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model. | |||||||||||||||||||||
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Keywords
