1. GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. 5-HT Receptor
    Dopamine Receptor
    Autophagy
  3. Sertindole

Sertindole (Synonyms: Lu 23-174)

Cat. No.: HY-14543 Purity: 96.14%
Handling Instructions

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available.

For research use only. We do not sell to patients.

Sertindole Chemical Structure

Sertindole Chemical Structure

CAS No. : 106516-24-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 103 In-stock
Estimated Time of Arrival: December 31
10 mg USD 94 In-stock
Estimated Time of Arrival: December 31
50 mg USD 424 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Description

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Target: Multi-target In vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors. Sertindole offers an alternative treatment option for refractory patients given its good EPS profile, favorable metabolic profile, and comparable efficacy to risperidone. Due to cardiovascular safety concerns, sertindole is available as a second-line choice for patients intolerant to other antipsychotic agents [1]. Sertindole should prove to be a very useful addition to the therapeutic options available for the treatment of psychotic disorders [2]. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS). Thus, sertindole is a useful option in the treatment of patients with schizophrenia [3].

Clinical Trial
Molecular Weight

440.94

Formula

C₂₄H₂₆ClFN₄O

CAS No.

106516-24-9

SMILES

FC1=CC=C(N2C3=CC=C(Cl)C=C3C(C4CCN(CCN5CCNC5=O)CC4)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2679 mL 11.3394 mL 22.6788 mL
5 mM 0.4536 mL 2.2679 mL 4.5358 mL
10 mM 0.2268 mL 1.1339 mL 2.2679 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SertindoleLu 23-1745-HT ReceptorDopamine ReceptorAutophagySerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Sertindole
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HY-14543
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