2. GPCR/G Protein Neuronal Signaling Autophagy
  3. 5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy
  4. Sertindole

Sertindole  (Synonyms: Lu 23-174)

Cat. No.: HY-14543 Purity: 99.75%
COA Handling Instructions

Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.

For research use only. We do not sell to patients.

Sertindole Chemical Structure

Sertindole Chemical Structure

CAS No. : 106516-24-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 63 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 63 In-stock
Solid
5 mg USD 58 In-stock
10 mg USD 94 In-stock
50 mg USD 424 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Sertindole:

Sertindole Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms
α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells[1][2][3].

IC50 & Target

5-HT2A Receptor

 

5-HT2C Receptor

 

In Vitro

Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells[2].
Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro[2].
Sertindole (5 μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sertindole Related Antibodies

Cell Proliferation Assay[2]

Cell Line: SUM159 and MCF-10A cells
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Showed IC50s of 9.2 µM and 27.6 µM for SUM159 and MCF-10A cells, respectively.

Cell Proliferation Assay[2]

Cell Line: NCI-H460, A549, NCI-H446, NCI-H661, 801-D, U251, A172, U118-MG, U87-MG, AGS, MKN45, BGC-823, SGC-7901, HT-29, COLO205, SW480, SW620, HCT-15, HepG2, Bel-7402, MCF-7, MDA-MB-231, SUM159, T47D, MDA-MB-453, ZR-75-1, CCRF-CEM, K562, Jurkat, MCF-10A cells
Concentration: 0.8-27.6 μM
Incubation Time: 48 hours
Result: Showed IC50s ranging between 0.8-12.7 µM, 2.7-4.6 µM, 12.7-15.3 µM and 8.6-16.1 µM for breast cancer, leukemia, hepatoma and glioblastoma lines, respectively.

Cell Migration Assay [2]

Cell Line: SUM159 cells
Concentration: 5 μΜ and 10 μΜ
Incubation Time: 24 hours
Result: Blocked around 50% cells traversing the membranes at 5 μΜ, and almost all the cells lost traversing ability at 10 μΜ.
Elevated LC3II conversion significantly (P < 0.01).
In Vivo

Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immune-deficient Balb/c mice implanted MDA-MB-231 human TNBC cells[2]
Dosage: 10 mg/kg
Administration: Oral gavage; 10 mg/kg; once daily; 12 days
Result: Exhibited a 22.7% reduction in size after a 12-day administration regimen.
Clinical Trial
Molecular Weight

440.94

Appearance

Solid

Formula

C24H26ClFN4O
CAS No.
SMILES

FC1=CC=C(N2C3=CC=C(Cl)C=C3C(C4CCN(CCN5CCNC5=O)CC4)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (56.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2679 mL 11.3394 mL 22.6788 mL
5 mM 0.4536 mL 2.2679 mL 4.5358 mL
10 mM 0.2268 mL 1.1339 mL 2.2679 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.75%

COA (254 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Sertindole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Sertindole106516-24-9Lu 23-1745-HT ReceptorDopamine ReceptorAdrenergic ReceptorAutophagySerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorantipsychotic activityanti-proliferative activityMCF-10ANCI-H460A549NCI-H446NCI-H661801-DU251A172U118-MGU87-MGAGSMKN45BGC-823SGC-7901HT-29COLO205SW480SW620HCT-15HepG2Bel-7402MCF-7MDA-MB-231SUM159T47DMDA-MB-453ZR-75-1CCRF-CEMK562JurkatInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Sertindole
Cat. No.:
HY-14543
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.