1. Neuronal Signaling
    GPCR/G Protein
  2. 5-HT Receptor
    Dopamine Receptor

Sertindole (Synonyms: Lu 23-174)

Cat. No.: HY-14543 Purity: 99.79%
Data Sheet SDS Handling Instructions

Sertindole, a neuroleptic, is one of the newer antipsychotic medications available.

For research use only. We do not sell to patients.
Sertindole Chemical Structure

Sertindole Chemical Structure

CAS No. : 106516-24-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 103 In-stock
10 mg USD 94 In-stock
50 mg USD 424 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Target: Multi-target In vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors. Sertindole offers an alternative treatment option for refractory patients given its good EPS profile, favorable metabolic profile, and comparable efficacy to risperidone. Due to cardiovascular safety concerns, sertindole is available as a second-line choice for patients intolerant to other antipsychotic agents [1]. Sertindole should prove to be a very useful addition to the therapeutic options available for the treatment of psychotic disorders [2]. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS). Thus, sertindole is a useful option in the treatment of patients with schizophrenia [3].

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Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2679 mL 11.3394 mL 22.6788 mL
5 mM 0.4536 mL 2.2679 mL 4.5358 mL
10 mM 0.2268 mL 1.1339 mL 2.2679 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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