2. PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. Akt STAT Apoptosis
  4. STAT3/AKT-IN-1

STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

STAT3/AKT-IN-1

STAT3/AKT-IN-1 構造式

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

STAT3/AKT-IN-1 関連抗体

Top Publications Citing Use of Products

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Akt Akt1 Akt2 Akt3

STAT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells[1].

IC50 & Target

Stat-3

 

体外実験

STAT3/AKT-IN-1 inihibits cell viability of gastric cancer cells SGC-7901 and BGC-823 with IC50s of 1.39 μM and 2.92 μM, respectively[1].
STAT3/AKT-IN-1 (2.5-10 μM) inhibits proliferation and migration, induces apoptosis by triggering cell cycle arrest at G2/M phase in SGC-7901 in a dose-dependent manner[1]. Migration assay[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3/AKT-IN-1 関連抗体

Cell Migration Assay [1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Inhibited migration of SGC-7901 cells.

Cell Cycle Analysis[1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Arrested cell cycle at G2/M phase.

Western Blot Analysis[1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 18 h
Result: Inhibited phosphorylation of AKT (Ser473) and STAT3 (Tyr705).
体内実験

STAT3/AKT-IN-1 (15 mg/kg, i.p., daily for 20 days) exhibits anticancer activity without significant toxicity in SGC-7901 xenografted BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SGC-7901 xenografted BALB/c mice[1]
Dosage: 15 mg/kg
Administration: i.p. once daily for 20 days
Result: Inhibited tumor growth without weight loss.
分子量

362.42

分子式

C23H22O4
SMILES

O=C1/C(CC/C1=C\C=C\C2=CC=CC=C2OC)=C/C3=CC=C(O)C(OC)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

STAT3/AKT-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3/AKT-IN-1AktSTATApoptosisPKBProtein kinase Bgastric cancerSGC-7901BGC-823STAT3AKTInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
STAT3/AKT-IN-1
製品番号:
HY-161351
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.