2. PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. Akt STAT Apoptosis
  4. STAT3/AKT-IN-1

STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells.

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STAT3/AKT-IN-1 Chemical Structure

STAT3/AKT-IN-1 Chemical Structure

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STAT3/AKT-IN-1 Related Antibodies

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Description

STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells[1].

IC50 & Target

Stat-3

 

In Vitro

STAT3/AKT-IN-1 inihibits cell viability of gastric cancer cells SGC-7901 and BGC-823 with IC50s of 1.39 μM and 2.92 μM, respectively[1].
STAT3/AKT-IN-1 (2.5-10 μM) inhibits proliferation and migration, induces apoptosis by triggering cell cycle arrest at G2/M phase in SGC-7901 in a dose-dependent manner[1]. Migration assay[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3/AKT-IN-1 Related Antibodies

Cell Migration Assay [1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Inhibited migration of SGC-7901 cells.

Cell Cycle Analysis[1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Arrested cell cycle at G2/M phase.

Western Blot Analysis[1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 18 h
Result: Inhibited phosphorylation of AKT (Ser473) and STAT3 (Tyr705).
In Vivo

STAT3/AKT-IN-1 (15 mg/kg, i.p., daily for 20 days) exhibits anticancer activity without significant toxicity in SGC-7901 xenografted BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SGC-7901 xenografted BALB/c mice[1]
Dosage: 15 mg/kg
Administration: i.p. once daily for 20 days
Result: Inhibited tumor growth without weight loss.
Molecular Weight

362.42

Formula

C23H22O4
SMILES

O=C1/C(CC/C1=C\C=C\C2=CC=CC=C2OC)=C/C3=CC=C(O)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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STAT3/AKT-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3/AKT-IN-1AktSTATApoptosisPKBProtein kinase Bgastric cancerSGC-7901BGC-823STAT3AKTInhibitorinhibitorinhibit

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