Tubulin polymerization-IN-44

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Tubulinpolymer-in-44 (compound 7w) is a strong and effective Tubulin inhibitor, with an IC₅₀ value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-44 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 0.21 μM (Tubulin)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	0.341 μM Compound: 7w	Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
HT-1080	IC₅₀	1.18 μM Compound: 7w	Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
HUVEC	IC₅₀	13.15 μM Compound: 7w	Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
MCF7	IC₅₀	2.13 μM Compound: 7w	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
SGC-7901	IC₅₀	0.21 μM Compound: 7w	Antiproliferative activity against human SGC-7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]

In Vitro

Tubulin polymerization-IN-44 (0.42 μM, 24 h- 48 h ) shows antiproliferative activity against SGC-7910 cells (IC₅₀ values of 0.21 μM)^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis

Cell Line:	SGC-7901 cells^[1]
Concentration:	0.42 μM
Incubation Time:	24 h- 48 h
Result:	Extended up the percentage of cells in G2/M phase from 10% to 42% (24 h) after treatment. Induced cell apoptosis at about 48 h.

In Vivo

Tubulin Polymers-in-44 (5-20 mg/kg every other day) inhibits tumor growth in a mouse model of breast cancer 4T1 cells without reducing body weight loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c female mice (mouse breast cancer 4T1 cells )^[1]
Dosage:	5, 10, and 20 mg/kg; every other day
Administration:	intravenous injection (i.c.) ;12-day.
Result:	Inhibited tumor growth with the rate of 49.2%, 58.1% and 84.0% at the dose of 5, 10 and 20 mg/kg ; Did not cause a decrease in animal body weight even at the high dose (20 mg/kg).

Molecular Weight

436.31

Formula

C₁₉H₁₅Cl₂N₃O₃S

SMILES

COC1=C(OC)C(OC)=CC(C2=NN3C(SC=C3C4=CC(Cl)=CC(Cl)=C4)=N2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Na Li, et al.Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]