2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-44

Tubulinpolymer-in-44 (compound 7w) is a strong and effective Tubulin inhibitor, with an IC50 value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-44 Chemical Structure

Tubulin polymerization-IN-44 Chemical Structure

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Tubulin polymerization-IN-44 Related Antibodies

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Description

Tubulinpolymer-in-44 (compound 7w) is a strong and effective Tubulin inhibitor, with an IC50 value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.

IC50 & Target

IC50: 0.21 μM (Tubulin)[1]
In Vitro

Tubulin polymerization-IN-44 (0.42 μM, 24 h- 48 h ) shows antiproliferative activity against SGC-7910 cells (IC50 values of 0.21 μM)[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-44 Related Antibodies

Cell Cycle Analysis

Cell Line: SGC-7901 cells[1]
Concentration: 0.42 μM
Incubation Time: 24 h- 48 h
Result: Extended up the percentage of cells in G2/M phase from 10% to 42% (24 h) after treatment.
Induced cell apoptosis at about 48 h.
In Vivo

Tubulin Polymers-in-44 (5-20 mg/kg every other day) inhibits tumor growth in a mouse model of breast cancer 4T1 cells without reducing body weight loss[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c female mice (mouse breast cancer 4T1 cells )[1]
Dosage: 5, 10, and 20 mg/kg; every other day
Administration: intravenous injection (i.c.) ;12-day.
Result: Inhibited tumor growth with the rate of 49.2%, 58.1% and 84.0% at the dose of 5, 10 and 20 mg/kg ;
Did not cause a decrease in animal body weight even at the high dose (20 mg/kg).
Molecular Weight

436.31

Formula

C19H15Cl2N3O3S
SMILES

COC1=C(OC)C(OC)=CC(C2=NN3C(SC=C3C4=CC(Cl)=CC(Cl)=C4)=N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization-IN-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-44Microtubule/TubulinCell apoptosisSGC-7901 cellsBreast cancer 4T1Tubulin inhibitor,Inhibitorinhibitorinhibit

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Tubulin polymerization-IN-44
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