Tubulin polymerization-IN-44
Tubulinpolymer-in-44 (compound 7w) is a strong and effective Tubulin inhibitor, with an IC50 value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.
For research use only. We do not sell to patients.
- Formula: C19H15Cl2N3O3S
- Molecular Weight:436.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.21 μM (Tubulin)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
0.341 μM
Compound: 7w
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Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 37182330] |
| HT-1080 | IC50 |
1.18 μM
Compound: 7w
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Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 37182330] |
| HUVEC | IC50 |
13.15 μM
Compound: 7w
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Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 37182330] |
| MCF7 | IC50 |
2.13 μM
Compound: 7w
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 37182330] |
| SGC-7901 | IC50 |
0.21 μM
Compound: 7w
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Antiproliferative activity against human SGC-7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 37182330] |
Tubulin polymerization-IN-44 (0.42 μM, 24 h- 48 h ) shows antiproliferative activity against SGC-7910 cells (IC50 values of 0.21 μM)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SGC-7901 cells[1]
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Concentration:0.42 μM
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Incubation Time:24 h- 48 h
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Result:Extended up the percentage of cells in G2/M phase from 10% to 42% (24 h) after treatment.
Induced cell apoptosis at about 48 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c female mice (mouse breast cancer 4T1 cells )[1]
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Dosage:5, 10, and 20 mg/kg; every other day
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Administration:intravenous injection (i.c.) ;12-day.
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Result:Inhibited tumor growth with the rate of 49.2%, 58.1% and 84.0% at the dose of 5, 10 and 20 mg/kg ;
Did not cause a decrease in animal body weight even at the high dose (20 mg/kg).
Chemical Information
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Molecular Weight 436.31
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Formula C19H15Cl2N3O3S
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SMILES
COC1=C(OC)C(OC)=CC(C2=NN3C(SC=C3C4=CC(Cl)=CC(Cl)=C4)=N2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-44 Related Classifications
HY-155686 Related Classifications
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