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Cat. No.: HY-161338

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Tubulin polymerization-IN-61

Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model.

For research use only. We do not sell to patients.

CAS No.: 2758114-60-0
Formula: C₂₂H₂₁N₃O₅
Molecular Weight:407.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Tubulin polymerization-IN-61 Chemical Structure

CAS No.: 2758114-60-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	32 nM Compound: 9a	Antiproliferative activity against mouse 4T1 cells measured after 72 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells measured after 72 hrs by MTT assay	[PMID: 38471357]
A549	IC₅₀	0.045 μM Compound: 9a	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 38471357]
MCF7	IC₅₀	0.02 μM Compound: 9a	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 38471357]
MCF7	IC₅₀	0.027 μM Compound: 17a	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
SGC-7901	IC₅₀	0.014 μM Compound: 9a	Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay	[PMID: 38471357]

In Vitro

Tubulin polymerization-IN-61 shows antiproliferative activity against three human cancer cell lines (MCF-7, SGC-7901 and A549), with IC₅₀ values ranging from 14 to 45 nM^[1].
Tubulin polymerization-IN-61 (20-60 nM,24 h) increases the proportion of MCF-7 cells in G2/M cycle from 14% to 50%, induces apoptosis, and inhibits MCF-7 cells migration and colony formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tubulin polymerization-IN-61 (5 or 15 mg/kg, i.v., every two days for 2 weeks) shows anti-tumor effects in BALB/c mice 4T1 xenograft tumor model, with negligible toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2758114-60-0
Molecular Weight 407.42
Formula C₂₂H₂₁N₃O₅
SMILES

OC1=CC(C2=CC=C3N=NN(C4=CC(OC)=C(OC)C(OC)=C4)C3=C2)=CC=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mingxin Huang, et al. Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors. European Journal of Medicinal Chemistry. Volume 269, 5 April 2024, 116309.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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