Tubulin polymerization-IN-61 

Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model^[1].

Tubulin polymerization-IN-61 shows antiproliferative activity against three human cancer cell lines (MCF-7, SGC-7901 and A549), with IC₅₀ values ranging from 14 to 45 nM^[1].
Tubulin polymerization-IN-61 (20-60 nM,24 h) increases the proportion of MCF-7 cells in G2/M cycle from 14% to 50%, induces apoptosis, and inhibits MCF-7 cells migration and colony formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-61 (5 or 15 mg/kg, i.v., every two days for 2 weeks) shows anti-tumor effects in BALB/c mice 4T1 xenograft tumor model, with negligible toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

407.42

C₂₂H₂₁N₃O₅

2758114-60-0

OC1=CC(C2=CC=C3N=NN(C4=CC(OC)=C(OC)C(OC)=C4)C3=C2)=CC=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mingxin Huang, et al. Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors. European Journal of Medicinal Chemistry. Volume 269, 5 April 2024, 116309.