Sialidase

By Targets:	Biochemical Assay Reagents (2) Drug Derivative (1) Endogenous Metabolite (6) Fluorescent Dye (1) Glycosidase (1) Influenza Virus (1) Parasite (2) Reference Standards (1) Taste Receptor (3) β-glucuronidase (1)
By Research Areas:	Infection (5) Inflammation/Immunology (2) Metabolic Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125798

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 4 Publications Verification Neu5Ac2en; DANA	Influenza Virus	Infection
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .

HY-E70097

Sialidase (α2-3-6-8-9)	Endogenous Metabolite	Others
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling .

HY-P2988

Neuraminidase, Microorganism 1 Publications Verification Exo-α-Sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

HY-W020790

Sialyl-Lewis X 1 Publications Verification sLeX	Endogenous Metabolite	Inflammation/Immunology
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-122351A

Advantame	Taste Receptor	Others
Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K ⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .

HY-N1470

Plantagoside	Glycosidase	Metabolic Disease
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-145533

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid KDN	Biochemical Assay Reagents	Others
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a type of sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be hydrolyzed by sialidase from the loach (Misgurnus fossilis) .

HY-E70043

*Ganglioside sialidase* (AuSialidase S)** Sialidase isoenzyme S; AuSialidase S	Endogenous Metabolite	Metabolic Disease
Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .

HY-N7529

Siastatin B	Endogenous Metabolite β-glucuronidase	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of *sialidase, β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

HY-E70073

*Ganglioside sialidase* (AuSialidase M2)** Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-E70019

*alpha-2-3,6-sialidase* (BiNanH2)**	Endogenous Metabolite	Metabolic Disease
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors .

HY-172951

Antitrypanosomal agent 23	Parasite	Infection
Antitrypanosomal agent 23 is an antitrypanosomal agent. Antitrypanosomal agent 23 has activity against intracellular amastigotes of T. cruzi in LLC-MK2 and C2C12 cells (IC₅₀: 0.10 and 0.11 μM). Antitrypanosomal agent 23 is a weak inhibitor of Recombinant trans-sialidase* from T. cruzi* (TcTS) (IC₅₀: 1.1 mM) .

HY-122351

Advantame free acid	Drug Derivative Taste Receptor	Others
Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K ⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .

HY-122351AR

Advantame (Standard)	Reference Standards Taste Receptor	Others
Advantame (Standard) is the analytical standard of Advantame. This product is intended for research and analytical applications. Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K ⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .

HY-D2982

BTP9-Neu5Ac	Fluorescent Dye	Infection
BTP9-Neu5Ac is a fluorescent imaging probe specifically designed for detecting the neuraminidase (NA) sialidase activity of influenza viruses. BTP9-Neu5Ac can visualize the intracellular Golgi localization of the viral NA activity. BTP9-Neu5Ac can be used for precise and temporal monitoring of the key enzyme activities during the viral life cycle .

HY-W040126

Tn antigen GalNAcα-O-Ser	Parasite	Infection
Tn Antigen (Tn Epitope) (Compound 1) is a Trypanosoma cruzi trans-sialidase (TcTS) inhibitor with inhibition rate of 57% at 1 mM. Tn Antigen shows anti-trypanosomal activity with an IC₅₀ of >0.5 mM. Tn Antigen can be used for the research of Chagas’ disease .

Cat. No.	Product Name	Type

HY-D2982

BTP9-Neu5Ac	Fluorescent Dyes
BTP9-Neu5Ac is a fluorescent imaging probe specifically designed for detecting the neuraminidase (NA) sialidase activity of influenza viruses. BTP9-Neu5Ac can visualize the intracellular Golgi localization of the viral NA activity. BTP9-Neu5Ac can be used for precise and temporal monitoring of the key enzyme activities during the viral life cycle .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990988

Efgitasialase alfa	Inhibitory Antibodies	Inflammation/Immunology
HY-P990988 is an *Sialidase-2*-targeting Fusion Protein .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W020790

Sialyl-Lewis X 1 Publications Verification sLeX	Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-N1470

Plantagoside	Plantaginaceae Structural Classification Flavonoids Classification of Application Fields Flavonones Phenols Polyphenols Metabolic Disease Plantago asiatica L. Plants Disease Research Fields Source Classification	Glycosidase
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

Species:	Virus (1) Human (2) Mouse (1)
Tag:	His (6) Myc (1)
Source:	HEK293 (2) Sf9 insect cells (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74732

	Neuraminidase Protein, C.perfringens (His) Sialidase; Neuraminidase; nanH	Virus	E. coli
	Neuraminidase is a subtype of sialidase associated with the pathogenic potential of microbial infections.As an enzyme, neuraminidase plays a crucial role in catalyzing the removal of terminal sialic acid residues from glycoproteins and glycolipids.Neuraminidase Protein, C.perfringens (His) is the recombinant Virus-derived Neuraminidase protein, expressed by E.coli , with N-His labeled tag.

HY-P77073

	Neuraminidase Protein, M.viridifaciens (His) Sialidase; Neuraminidase; nedA	Others	E. coli
	Neuraminidase is a subtype of sialidase associated with the pathogenic potential of microbial infections. As an enzyme, neuraminidase plays a crucial role in catalyzing the removal of terminal sialic acid residues from glycoproteins and glycolipids. Neuraminidase Protein, M.viridifaciens (His) is the recombinant Neuraminidase protein, expressed by E. coli , with N-His labeled tag.

HY-P702578

	Sialidase-2 Protein, Mouse (P.pastoris, His) Neu2; Sialidase-2; EC 3.2.1.18; Cytosolic Sialidase; Mouse skeletal muscle Sialidase; MSS; Murine thymic Sialidase; MTS; N-acetyl-alpha-neuraminidase 2	Mouse	P. pastoris
	Sialidase-2 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Sialidase-2, expressed by P. pastoris , with N-10*His labeled tag. ,

HY-P71310

	Sialidase-1 Protein, Human (HEK293, His) Sialidase-1; Acetylneuraminyl Hydrolase; G9 Sialidase; Lysosomal Sialidase; N-Acetyl-Alpha-Neuraminidase 1; NEU1; NANH	Human	HEK293
	The Sialidase-1 protein plays a crucial role in cellular processes by catalyzing the removal of the sialic acid (N-acetylneuraminic acid) moiety from glycoproteins and glycolipids. Its enzymatic activity is strictly dependent on its presence in multienzyme complexes, emphasizing the cooperative nature of its function. Sialidase-1 Protein, Human (HEK293, His) is the recombinant human-derived Sialidase-1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74733

	NEU2 Protein, Human (HEK293, His) Sialidase-2; Cytosolic Sialidase; N-acetyl-alpha-neuraminidase 2; NEU2	Human	HEK293
	NEU2 protein acts as an exo-α sialidase and selectively hydrolyzes terminal sialic acids in glycolipids, glycoproteins, and oligosaccharides. It shows specificity for α-(2->3)-sialylated GD1a and GT1B gangliosides, preferring α-(2->3) over α-(2->8)-sialylated GD1b. NEU2 Protein, Human (HEK293, His) is the recombinant human-derived NEU2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72062

	NEU2 Protein, Cricetulus griseus (sf9, His-Myc) NEU2; Sialidase-2; EC 3.2.1.18; Cytosolic Sialidase; N-acetyl-alpha-neuraminidase 2	Others	Sf9 insect cells
	The NEU2 protein plays a key role in cellular processes by catalyzing the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides, and gangliosides. Through its enzymatic activity, NEU2 contributes to the controlled modification of cell surface glycoconjugates, affecting various cellular functions including cell adhesion, signaling, and immune responses. NEU2 Protein, Cricetulus griseus (sf9, His-Myc) is the recombinant NEU2 protein, expressed by sf9 insect cells , with N-10*His, C-Myc labeled tag.

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Sialidase

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