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Ten-eleven-translocation (TET) protein

" in MedChemExpress (MCE) Product Catalog:

標的別:	TET Protein (10) ADC Linker (19) Amino Acid Derivatives (2) Apoptosis (1) Bacterial (6) Biochemical Assay Reagents (1) DNA Methyltransferase (4) DNA Stain (2) DNA/RNA Synthesis (1) Endogenous Metabolite (7) Fluorescent Dye (6) GABA Receptor (2) Hapten (1) Histone Demethylase (5) Histone Methyltransferase (1) Isotope-Labeled Compounds (2) MOFs (1) Oct3/4 (1) PKC (1) Potassium Channel (1) PROTAC Linkers (1) Small Interfering RNA (siRNA) (9) STAT (2) Wnt (1) β-catenin (1)
研究分野別:	Cancer (34) Cardiovascular Disease (1) Endocrinology (1) Infection (5) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (7)
クリックケミストリー:	ADC Synthesis (17) Labeling and Fluorescence Imaging (5) PROTAC Synthesis (1) Tetrazine (23)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (9)

阻害剤およびアゴニスト

蛍光色素

生化学アッセイ試薬

ペプチド

天然物

組換えタンパク質

同位体標識化合物

抗体

クリックケミストリー

オリゴヌクレオチド

Targets Recommended: TET Protein

製品番号	製品名	Target	研究分野	構造式

HY-402410

TETi76 1 Publications Verification	TET Protein	Cancer
TETi76 is an orally active *TET* family inhibitor with IC₅₀ values ??of 1.5, 9.4 and 8.8 μM for *TET1, TET2* and *TET3, respectively. TETi76 competitively binds to the active site of TET* enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of *TET2* mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research .

HY-111558

Bobcat339 Maximum Cited Publications 22 Publications Verification	DNA Methyltransferase TET Protein	Cancer
Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC₅₀s of 33 μM and 73 μM for *TET1* and *TET2*, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .

HY-111558A

Bobcat339 hydrochloride Maximum Cited Publications 22 Publications Verification	DNA Methyltransferase TET Protein	Cancer
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC₅₀s of 33 μM and 73 μM for *TET1* and *TET2*, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-12303

OAC1 1 Publications Verification	Oct3/4 TET Protein	Cancer
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and *TET1*. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-122258

NSC-370284	STAT TET Protein	Cancer
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-P11094

Tet1-Cys peptide	TET Protein	Neurological Disease
Tet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor GT1b, possessing neuronal targeting capabilities. The Tet1-Cys peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery .

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium 2-Hydroxyglutarate-13C5 disodium; 2-Hydroxyglutaric acid-13C5 disodium; 2-Hydroxypentanedioic acid-13C5 disodium	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-129079A

TFMB-(S)-2-HG 2 Publications Verification	DNA Methyltransferase Wnt β-catenin	Endocrinology Cancer
TFMB-(S)-2-HG is a potent *TET2* inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML) .

HY-W018324

5-Hydroxymethylcytosine 5hmC	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-120395

UC-514321 1 Publications Verification	STAT Apoptosis TET Protein	Inflammation/Immunology Cancer
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses *TET1* expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium 2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium	Histone Demethylase Endogenous Metabolite	Cancer
α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research .

HY-133505

*Me-Tet-PEG4-NH2 hydrochloride*	PROTAC Linkers	Cancer
Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-160638

NSC-311068	TET Protein	Cancer
NSC-311068 is *TET1* inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1 .

HY-170747A

9-tert-Butyldoxycycline hydrochloride	Bacterial	Infection Inflammation/Immunology
9-tert-Butyldoxycycline hydrochloride exhibits immunomodulatory activity, alters the polarization states polymorphonuclear neutrophils, and ameliorates the inflammatory response in ischemia-reperfusion injury model. 9-tert-Butyldoxycycline hydrochloride is the ligand for ‘Tet-On’ switch system .

HY-P5486

Tet-20	Bacterial	Others
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)

HY-177764

Tet-v2.0-ethyl	Amino Acid Derivatives	Others
Tet-v2.0-ethyl is a tetrazine non-canonical amino acid. Tet-v2.0-ethyl can stably exist within living cells without being degraded, enabling in situ labeling of intracellular biomolecules. Tet-v2.0-ethyl is mainly used as a bioorthogonal labeling tool compound .

HY-156313

*Me-Tet-PEG4-NHS*	ADC Linker	Cancer
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-P3459

Tet-213	Bacterial	Infection
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .

HY-P3459A

Tet-213 TFA 1 Publications Verification	Bacterial	Infection
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .

HY-RS23091

Tet2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet2 Rat Pre-designed siRNA Set A Tet2 Rat Pre-designed siRNA Set A

HY-RS23219

Tet1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet1 Rat Pre-designed siRNA Set A Tet1 Rat Pre-designed siRNA Set A

HY-RS14385

TET2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TET2 Human Pre-designed siRNA Set A contains three designed siRNAs for TET2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TET2 Human Pre-designed siRNA Set A TET2 Human Pre-designed siRNA Set A

HY-W591272A

*Me-Tet-PEG3-NH2 hydrochloride*	ADC Linker	Cancer
Me-Tet-PEG3-NH2 hydrochloride is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 hydrochloride can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups .

HY-W591272

*Me-Tet-PEG3-NH2*	ADC Linker	Cancer
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups .

HY-156308

*Me-Tet-PEG4-Maleimide*	ADC Linker	Cancer
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-D0828

3,6-Dichlorotrimellitic acid	DNA Stain MOFs	Others
3,6-Dichlorotrimellitic acid is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.

HY-D0829

3,6-Dichlorotrimellitic anhydride	DNA Stain	Others
3,6-Dichlorotrimellitic anhydride is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.

HY-W396714

Succinic acid sodium Wormwood acid sodium	Potassium Channel TET Protein	Cardiovascular Disease Neurological Disease
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and *TET1* (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research .

HY-P5486A

Tet-20 acetate	Bacterial	Infection
Tet-20 acetate is a broad-spectrum antimicrobial peptide. Tet-20 acetate is promising for research of Gram-negative and Gram-positive bacteria (e.g., P. aeruginosa, S. aureus) .

HY-156493

*Me-Tet-PEG5-COOH*	ADC Linker	Cancer
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-RS24852

Tet3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet3 Rat Pre-designed siRNA Set A Tet3 Rat Pre-designed siRNA Set A

HY-156307

*Me-Tet-PEG3-Maleimide*	ADC Linker	Cancer
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156312

*Me-Tet-PEG8-Maleimide*	ADC Linker	Cancer
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-170747

9-tert-Butyldoxycycline	Bacterial	Infection Inflammation/Immunology
9-tert-Butyldoxycycline exhibits immunomodulatory activity, alters the polarization states polymorphonuclear neutrophils, and ameliorates the inflammatory response in ischemia-reperfusion injury model. 9-tert-Butyldoxycycline is the ligand for ‘Tet-On’ switch system .

HY-169432

TET-13	GABA Receptor	Neurological Disease
TET-13 is a positive allosteric modulator of GABA_A receptor with an EC₅₀ of 5.65 μM, lower than that of Etomidate (EC₅₀: 9.29 μM). TET-13 shows potent anesthetic effects in both mice and rats (ED₅₀: 0.48 mg/kg and 0.69 mg/kg, respectively) .

HY-131461

*6-TET* Dipivaloate**	Fluorescent Dye	Inflammation/Immunology
6-TET Dipivaloate is a nucleic acid sequencing probe.

HY-D1898

*6-TET* Azide**	Fluorescent Dye	Others
6-TET Azide is a fluorescent probe that can be used for the preparation of fluorescent contrast agent and nucleic acid sequencing .

HY-W018324S

5-Hydroxymethylcytosine-13C,d2 5hmC-¹³C,d₂	Isotope-Labeled Compounds	Neurological Disease
5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-D1897

*6-TET* phosphoramidite** 5′-Tetrachlorofluorescein phosphoramidite	Fluorescent Dye	Others
6-TET phosphoramidite (5′-Tetrachlorofluorescein phosphoramidite) is a fluorescent dye that can be used for labeling an oligonucleotide with fluorescein .

HY-156497

Biotin-PEG8-Me-Tet	Endogenous Metabolite	Others
Biotin-PEG8-Me-Tet is a biotin labeling .

HY-156492

*Me-Tet-PEG4-COOH*	ADC Linker	Cancer
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156494

*Me-Tet-PEG9-COOH*	ADC Linker	Cancer
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156491

*Me-Tet-PEG9-NHS*	ADC Linker	Cancer
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156475

*Me-Tet-PEG2-COOH*	ADC Linker	Cancer
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156495

Biotin-PEG3-Me-Tet	ADC Linker	Cancer
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156479

*Me-Tet-PEG3-NHBoc*	ADC Linker	Cancer
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156476

*Me-Tet-PEG2-NHS*	ADC Linker	Cancer
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

製品番号	製品名	Type

HY-D0828

3,6-Dichlorotrimellitic acid	蛍光色素
3,6-Dichlorotrimellitic acid is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.

HY-D0829

3,6-Dichlorotrimellitic anhydride	蛍光色素
3,6-Dichlorotrimellitic anhydride is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.

HY-131461

*6-TET* Dipivaloate**	蛍光色素
6-TET Dipivaloate is a nucleic acid sequencing probe.

HY-D1898

*6-TET* Azide**	蛍光色素
6-TET Azide is a fluorescent probe that can be used for the preparation of fluorescent contrast agent and nucleic acid sequencing .

HY-D1897

*6-TET* phosphoramidite** 5′-Tetrachlorofluorescein phosphoramidite	蛍光色素
6-TET phosphoramidite (5′-Tetrachlorofluorescein phosphoramidite) is a fluorescent dye that can be used for labeling an oligonucleotide with fluorescein .

HY-D2116

TAMRA-PEG8-Me-Tet	蛍光色素
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2117

TAMRA-PEG4-Me-Tet	蛍光色素
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet	蛍光色素
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-114290

6-TET	蛍光色素

HY-13689G

Go 6983

蛍光色素

Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury .

製品番号	製品名	Type

HY-13689G

Go 6983

生化学アッセイ試薬

製品番号	製品名	Target	研究分野

HY-P11094

Tet1-Cys peptide	TET Protein	Neurological Disease
Tet1-Cys peptide is a peptide with the sequence HLNILSTLWKYRC. Tet1 (HLNILSTLWKYR) (HY-P10998) can specifically bind to the neuronal ganglioside receptor GT1b, possessing neuronal targeting capabilities. The Tet1-Cys peptide sequence has an added Cys, which can be used for drug conjugation for research on drug delivery .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research .

HY-P2514

TET 830 modified/T-helper epitope from tetanus toxoid	ペプチド	Inflammation/Immunology
TET 830 modified/T-helper epitope from tetanus toxoid is a modified T-helper epitope from tetanus toxoid. TET 830 modified/T-helper epitope from tetanus toxoid induces T-cells responses and is used as a helper peptide in vaccinations .

HY-P5486

Tet-20	Bacterial	Others
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)

HY-P3459

Tet-213	Bacterial	Infection
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .

HY-P3459A

Tet-213 TFA 1 Publications Verification	Bacterial	Infection
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .

HY-P5486A

Tet-20 acetate	Bacterial	Infection
Tet-20 acetate is a broad-spectrum antimicrobial peptide. Tet-20 acetate is promising for research of Gram-negative and Gram-positive bacteria (e.g., P. aeruginosa, S. aureus) .

製品番号	製品名	Category	Target	構造式

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-W018324

5-Hydroxymethylcytosine 5hmC	天然物 Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

製品番号	Compare	製品名	Species	Source	Image

HY-P702914

	TET1 Protein, Human (sf9, FLAG) CXXC6; KIAA1676; LCX	Human	Sf9 insect cells
	TET1 Protein, Human (sf9, FLAG) is the recombinant human-derived TET1, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

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製品番号	製品名	構造式

HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-W018324S

5-Hydroxymethylcytosine-13C,d2

5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-W704805

Sodium 2-hydroxypentanedioate-2,3,3-d3

Sodium 2-hydroxypentanedioate-2,3,3-d₃ is the deuterium labeled α-Hydroxyglutaric acid disodium (HY-113038A). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

Host:	Mouse (6)
Reactivity:	Human (6) Rat (2) Mouse (2)
Application:	IHC-P (6) ICC/IF (2) WB (2) FC (2) ELISA (2)
Isotype:	IgG1 (2) IgG2a (2) IgG2b (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

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HY-P88229

	TET3 Antibody (YA7913) hCG_40738	IHC-P	Human, Mouse, Rat
	TET3 Antibody (YA7913) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TET3.

HY-P84639

	TET2 Antibody (YA4336) MDS; KIAA1546	WB, IHC-P, ICC/IF, FC, ELISA	Human
	TET2 Antibody (YA4336) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TET2.

HY-P88065

	TET1 Antibody (YA7749) CXXC6; LCX	IHC-P	Human
	TET1 Antibody (YA7749) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TET1.

HY-P88229A

	TET3 Antibody (YA7913)(PBS only) hCG_40738	IHC-P	Human, Mouse, Rat
	TET3 Antibody (YA7913) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TET3.

HY-P84639A

	TET2 Antibody (YA4336)(PBS only) MDS; KIAA1546	WB, IHC-P, ICC/IF, FC, ELISA	Human
	TET2 Antibody (YA4336) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TET2.

HY-P88065A

	TET1 Antibody (YA7749)(PBS only) CXXC6; LCX	IHC-P	Human
	TET1 Antibody (YA7749) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TET1.

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Size	* This product has been "discontinued". Optimized version of product available: / 在庫あり - + カートに追加お問い合わせ

製品番号	製品名		Classification

HY-133505

*Me-Tet-PEG4-NH2 hydrochloride*		PROTAC Synthesis Tetrazine
Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-156313

*Me-Tet-PEG4-NHS*		ADC Synthesis Tetrazine
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-W591272

*Me-Tet-PEG3-NH2*		Tetrazine ADC Synthesis
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups .

HY-156308

*Me-Tet-PEG4-Maleimide*		ADC Synthesis Tetrazine
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156493

*Me-Tet-PEG5-COOH*		ADC Synthesis Tetrazine
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156307

*Me-Tet-PEG3-Maleimide*		ADC Synthesis Tetrazine
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156312

*Me-Tet-PEG8-Maleimide*		Tetrazine ADC Synthesis
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156497

Biotin-PEG8-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
Biotin-PEG8-Me-Tet is a biotin labeling .

HY-156492

*Me-Tet-PEG4-COOH*		ADC Synthesis Tetrazine
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156494

*Me-Tet-PEG9-COOH*		ADC Synthesis Tetrazine
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156491

*Me-Tet-PEG9-NHS*		ADC Synthesis Tetrazine
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156475

*Me-Tet-PEG2-COOH*		Tetrazine ADC Synthesis
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156495

Biotin-PEG3-Me-Tet		Tetrazine Labeling and Fluorescence Imaging
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156479

*Me-Tet-PEG3-NHBoc*		Tetrazine ADC Synthesis
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156476

*Me-Tet-PEG2-NHS*		Tetrazine ADC Synthesis
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156478

*Me-Tet-PEG4-NHBoc*		ADC Synthesis Tetrazine
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156477

*Me-Tet-PEG8-NHBoc*		Tetrazine ADC Synthesis
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156490

*Me-Tet-PEG5-NHS*		ADC Synthesis Tetrazine
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-D2116

TAMRA-PEG8-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2117

TAMRA-PEG4-Me-Tet		Tetrazine Labeling and Fluorescence Imaging
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet		Tetrazine Labeling and Fluorescence Imaging
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-156301A

*Me-Tet-PEG8-NH2 hydrochloride*		ADC Synthesis Tetrazine
Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156300

*Me-Tet-PEG4-NH2*		Tetrazine ADC Synthesis
Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

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