2. Epigenetics
  3. TET Protein
  4. Tet1 peptide

Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research.

For research use only. We do not sell to patients.

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Tet1 peptide

Tet1 peptide Chemical Structure

CAS No. : 270919-17-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Tet1 peptide:

Tet1 peptide Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research[1][2].

In Vitro

Tet1 peptide conjugated with PEGylated poly(2-(N,N-dimethylamino)ethyl methacrylate) (PEG-PDMAEMA) forms siRNA nanocomplexes capable of achieving specific siRNA delivery to neurons[1].
Tet1 peptide functionalized on polymersomes and administered via cochleostomy mediates targeting of the polymersomes to the rat cochlear nerve; however, no targeting effect was observed following transtympanic injection.[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tet1 peptide Related Antibodies
In Vivo

Tet1 peptide-modified CT/siRNA nanocomplexes (60 μg siRNA per mouse; i.v.; single dose) achieve enhanced brain accumulation and localize near neurons in healthy ICR mice[1].
Tet1 peptide-modified CT/siRNA nanocomplexes (32 μg siRNA per mouse; i.v.; single dose) deliver siRNA to the brain of healthy ICR mice with a DTI of 2.62 and peak accumulation of 2.42 %ID/g-brain at 1 hour post-injection[1].
Tet1 peptide-modified CT/BACE1-siRNA nanocomplexes (80 μg siRNA per mouse; i.v.; every 5 days; 4 total doses) restore cognitive performance to wild-type levels, reduce BACE1 mRNA by ~27.6%, lower amyloid plaque burden by ~87.5%, and protect neurons while promoting neurogenesis in 8-month-old APP/PS1 Alzheimer's disease model mice[1].
Tet1 peptide-functionalized PEG-b-PCL polymersomes (40-100 µL; transtympanic injection, bilateral; cochleostomy, unilateral, via osmotic pump connected to scala tympani; single dose; 3 days duration) uniquely target tractus spiralis foraminosus region nerve fibers when delivered via cochleostomy, while sharing non-specific inner ear tissue distribution with control polymersomes across both delivery routes, and do not target the cochlear nerve via transtympanic injection (a pattern consistent across all PM types)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1543.81

Formula

C73H114N20O17
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

His-Leu-Asn-Ile-Leu-Ser-Thr-Leu-Trp-Lys-Tyr-Arg
Sequence Shortening

HLNILSTLWKYR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (64.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6477 mL 3.2387 mL 6.4775 mL
5 mM 0.1295 mL 0.6477 mL 1.2955 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6477 mL 3.2387 mL 6.4775 mL 16.1937 mL
5 mM 0.1295 mL 0.6477 mL 1.2955 mL 3.2387 mL
10 mM 0.0648 mL 0.3239 mL 0.6477 mL 1.6194 mL
15 mM 0.0432 mL 0.2159 mL 0.4318 mL 1.0796 mL
20 mM 0.0324 mL 0.1619 mL 0.3239 mL 0.8097 mL
25 mM 0.0259 mL 0.1295 mL 0.2591 mL 0.6477 mL
30 mM 0.0216 mL 0.1080 mL 0.2159 mL 0.5398 mL
40 mM 0.0162 mL 0.0810 mL 0.1619 mL 0.4048 mL
50 mM 0.0130 mL 0.0648 mL 0.1295 mL 0.3239 mL
60 mM 0.0108 mL 0.0540 mL 0.1080 mL 0.2699 mL
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Tet1 peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tet1 peptide270919-17-0TET ProteinTET enzymeTen-eleven-translocation (TET) proteinTen-eleven translocation (TET) methylcytosine dioxygenasesensorineural hearing losstrisialoganglioside clostridial toxin receptor (GT1b)neuronal cell typesBV2 microgliarat cochlear nerveHT22 neuronal cellsGT1B gangliosidesPC12 cellsalzheimer's diseaseCTX-TNA2 astrocytesInhibitorinhibitorinhibit

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