TFMB-(S)-2-HG
Based on 2 publication(s) in Google Scholar
TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 1445703-64-9
- Formula: C13H11F3O4
- Molecular Weight:288.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) TFMB-(S)-2-HG
MoreAll DNA Methyltransferase Isoforms
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Biological Activity
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Wnt3A |
TFMB-(S)-2-HG (200 μM, 7 days) inhibits the enhanced osteogenic differentiation of rBMSCs caused by hypomethylation and high expression of Cthrc1 under normal nutritional conditions and fluoride exposure[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:rBMSCs
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Concentration:200 μM
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Incubation Time:7 days
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Result:Diminished ALP staining and activity.
Reduced calcium mineralization.
Downregulated expression of osteogenic markers (Runx2, Osterix, ALP, Col1α1, BGP).
Decreased OPG/RANKL ratio.
Downregulated Wnt3a, β-catenin (intranuclear) protein expression.
Chemical Information
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CAS No. 1445703-64-9
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Appearance Solid
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Molecular Weight 288.22
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Formula C13H11F3O4
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Color White to light yellow
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SMILES
O=C([C@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Environ Pollut
Investigating the role and mechanism of methionine in different types of skeletal fluorosis based on Siglec-15 methylation. [Abstract]2026 Feb 1:390:127432. PMID: 41349947 -
Environ Pollut
Screening of differentially methylated genes in skeletal fluorosis of rats with different types and involvement of aberrant methylation of Cthrc1. [Abstract]2023 Sep 1:332:121931. PMID: 37268221
Solvent & Solubility
DMSO : 100 mg/mL (346.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
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- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625. [Content Brief]
[2]. Ding H, et al. Screening of differentially methylated genes in skeletal fluorosis of rats with different types and involvement of aberrant methylation of Cthrc1. Environ Pollut. 2023 Sep 1;332:121931. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4696 mL | 17.3478 mL | 34.6956 mL | 86.7390 mL |
| 5 mM | 0.6939 mL | 3.4696 mL | 6.9391 mL | 17.3478 mL | |
| 10 mM | 0.3470 mL | 1.7348 mL | 3.4696 mL | 8.6739 mL | |
| 15 mM | 0.2313 mL | 1.1565 mL | 2.3130 mL | 5.7826 mL | |
| 20 mM | 0.1735 mL | 0.8674 mL | 1.7348 mL | 4.3369 mL | |
| 25 mM | 0.1388 mL | 0.6939 mL | 1.3878 mL | 3.4696 mL | |
| 30 mM | 0.1157 mL | 0.5783 mL | 1.1565 mL | 2.8913 mL | |
| 40 mM | 0.0867 mL | 0.4337 mL | 0.8674 mL | 2.1685 mL | |
| 50 mM | 0.0694 mL | 0.3470 mL | 0.6939 mL | 1.7348 mL | |
| 60 mM | 0.0578 mL | 0.2891 mL | 0.5783 mL | 1.4456 mL | |
| 80 mM | 0.0434 mL | 0.2168 mL | 0.4337 mL | 1.0842 mL | |
| 100 mM | 0.0347 mL | 0.1735 mL | 0.3470 mL | 0.8674 mL |
TFMB-(S)-2-HG Related Classifications
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