1445703-64-9
1445703-64-9
Chemical Structure
TFMB-(S)-2-HG
- CAS No.: 1445703-64-9
- Formula:C13H11F3O4
- Molecular Weight:288.22
IUPAC Name: 3-(trifluoromethyl)benzyl (S)-5-oxotetrahydrofuran-2-carboxylate
InChIKey: UXTLNUGKDZMPTC-JTQLQIEISA-N
SMILES: O=C([C@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
Biological Activity: TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TFMB-(S)-2-HG | 99.79% | TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML). | ||||||||||||||||||||
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References
- [1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625. [Content Brief]
- [2]. Ding H, et al. Screening of differentially methylated genes in skeletal fluorosis of rats with different types and involvement of aberrant methylation of Cthrc1. Environ Pollut. 2023 Sep 1;332:121931. [Content Brief]
