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TFMB-(R)-2-HG 

Cat. No.: HY-129079 Purity: 98.33%
Handling Instructions

TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal.

For research use only. We do not sell to patients.

TFMB-(R)-2-HG Chemical Structure

TFMB-(R)-2-HG Chemical Structure

CAS No. : 1445700-01-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 159 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 290 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].

IC50 & Target

Carcinogenic factor[1]

Molecular Weight

288.22

Formula

C₁₃H₁₁F₃O₄

CAS No.

1445700-01-5

SMILES

O=C([[email protected]@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (867.39 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4696 mL 17.3479 mL 34.6957 mL
5 mM 0.6939 mL 3.4696 mL 6.9391 mL
10 mM 0.3470 mL 1.7348 mL 3.4696 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TFMB-(R)-2-HGOthersInhibitorinhibitorinhibit

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Product name:
TFMB-(R)-2-HG
Cat. No.:
HY-129079
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