country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-169432

Copy Link Print Information

TET-13

TET-13 is a positive allosteric modulator of GABA_A receptor with an EC₅₀ of 5.65 μM, lower than that of Etomidate (EC₅₀: 9.29 μM). TET-13 shows potent anesthetic effects in both mice and rats (ED₅₀: 0.48 mg/kg and 0.69 mg/kg, respectively).

For research use only. We do not sell to patients.

Formula: C₁₅H₁₆N₂O₃S
Molecular Weight:304.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

TET-13 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

TET-13 (1 mg/mL, 0-30 min) is rapidly metabolized in SD rat plasma with a half-life T_1/2 of 0.48 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TET-13 (1.2 mg/kg for mice, 1.725 mg/kg for rats, i.v.) shows potent anesthetic effects in both mice and rats (ED₅₀: 0.48 mg/kg and 0.69 mg/kg, respectively), with a faster recovery than Etomidate^[1].
TET-13 (1.38 mg/kg, i.v.) shows little inhibition on cortisone of rat serum, indicating it has no effect on cortisol biosynthesis^[1].
TET 13 (22 mg/kg/h) continuous infusion induces shorter recovery times and walking times than Etomidate in rats at 0.5, 1 and 2 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice, rats^[1]
Dosage:

2.5 ×ED₅₀ (ED₅₀: 0.48 mg/kg (mice) and 0.69 mg/kg, (rats))
Administration:

Intravenous injection (i.v.)
Result:

Exhibited faster recovery compared to Etomidate (the times to walk: 27.88 s and 107.80 s, respectively) in mice.
Showed the incidence of myoclonus is 100% in mice.
Showed faster onset time (3.04 s) than etomidate in rats.
Showed the incidence of myoclonus was 0 % in rats.

Chemical Information

Molecular Weight 304.36
Formula C₁₅H₁₆N₂O₃S
SMILES

COC(CSC(C1=CN=CN1[C@H](C)C2=CC=CC=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu, et al. Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression. Bioorganic chemistry. 2024, 154, 107997. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote