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Toxoplasmosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aminoacyl-tRNA Synthetase (1) Antibiotic (18) Antifolate (1) Apoptosis (1) Autophagy (1) Bacterial (13) Bcr-Abl (1) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (1) Environmental Pollutants (1) Ferroptosis (1) Herbicide (1) Interleukin Related (1) Isotope-Labeled Compounds (5) Microtubule/Tubulin (1) NF-κB (1) p38 MAPK (1) Parasite (26) PI3K (1) Reactive Oxygen Species (ROS) (3) Reference Standards (6) Src (1)
By Research Areas:	Cancer (2) Infection (31) Inflammation/Immunology (3)

By Targets:

Akt (1)

Aminoacyl-tRNA Synthetase (1)

Antibiotic (18)

Antifolate (1)

Apoptosis (1)

Autophagy (1)

Bacterial (13)

Bcr-Abl (1)

Cytochrome P450 (4)

Dihydrofolate reductase (DHFR) (1)

Environmental Pollutants (1)

Ferroptosis (1)

Herbicide (1)

Interleukin Related (1)

Isotope-Labeled Compounds (5)

Microtubule/Tubulin (1)

NF-κB (1)

p38 MAPK (1)

Parasite (26)

PI3K (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (6)

Src (1)

By Research Areas:

Cancer (2)

Infection (31)

Inflammation/Immunology (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13832

Atovaquone 4 Publications Verification Atavaquone	Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the *parasite’s mitochondrial cytochrome bc1* complex*. Atovaquone is against human and P. falciparum* cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-B0688

Dapsone 4 Publications Verification 4,4′-Diaminodiphenyl sulfone; DDS	Antibiotic Parasite Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-B0273

Sulfadiazine Maximum Cited Publications 8 Publications Verification	Bacterial Parasite Antibiotic	Infection
Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-B1916

Acetylspiramycin 2 Publications Verification Spiramycin B; Spiramycin II; Foromacidin B	Antibiotic Bacterial Parasite	Infection
Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection .

HY-B0357

Diclazuril 2 Publications Verification R-64433	Parasite Antibiotic	Infection
Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-B0357S

Diclazuril-d4 R-64433-d₄	Isotope-Labeled Compounds Parasite Antibiotic	Infection
Diclazuril-d₄ is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-B1350A

Fusidic acid sodium salt 2 Publications Verification Sodium fusidate; SQ-16360	Bacterial Antibiotic Interleukin Related	Infection Inflammation/Immunology
Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .

HY-B0273A

Sulfadiazine sodium Maximum Cited Publications 8 Publications Verification	Bacterial Parasite Antibiotic	Infection
Sulfadiazine sodium is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-13833

Endochin	Parasite	Infection
Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC₅₀ of 0.003 nM. Endochin is also active against experimental toxoplasmosis .

HY-B0273S

Sulfadiazine-d4	Bacterial	Infection
Sulfadiazine-d₄ is a deuterium labeled Sulfadiazine. Sulfadiazine is a sulfonamide antibiotic used for the treatment of toxoplasmosis .

HY-B0273R

Sulfadiazine (Standard)	Reference Standards Bacterial Parasite Antibiotic	Infection
Sulfadiazine (Standard) is the analytical standard of Sulfadiazine. This product is intended for research and analytical applications. Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-161666

mCMY416	Aminoacyl-tRNA Synthetase Parasite	Infection
mCMY416 is an orally active and blood brain barrier (BBB) permeability apicomplexan phenylalanine tRNA synthetase inhibitor, and shows antiparasitic activity .

HY-171190

ELQ-316	Parasite	Infection
ELQ-316 is an endochinlike quinolone compound and an anti-parasite agent. ELQ-316 demonstrates a great efficacy against acute and chronic experimental toxoplasmosis .

HY-13832R

Atovaquone (Standard) Atavaquone (Standard)	Reference Standards Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Standard) is the analytical standard of Atovaquone. This product is intended for research and analytical applications. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the *parasite’s mitochondrial cytochrome bc1* complex*. Atovaquone is against human and P. falciparum* cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-B0273B

Sulfadiazine 100 µg/mL in methanol Maximum Cited Publications 8 Publications Verification	Parasite Bacterial Environmental Pollutants	Infection
Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection .

HY-13832S

Atovaquone-d4	Isotope-Labeled Compounds Parasite	Infection
Atovaquone-d₄ is the deuterium labeled Atovaquone. Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-B0273AR

Sulfadiazine sodium (Standard)	Reference Standards Bacterial Parasite Antibiotic	Infection
Sulfadiazine (sodium) (Standard) is the analytical standard of Sulfadiazine (sodium). This product is intended for research and analytical applications. Sulfadiazine sodium is a sulfonamide?antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-137439

Fanotaprim VYR-006	Antifolate	Infection
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC₅₀s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim has the potential for the research of toxoplasmosis .

HY-128397

CpCDPK1/TgCDPK1-IN-1	Parasite Bcr-Abl Src	Infection
CpCDPK1/TgCDPK1-IN-1 (compound 7p) is a potent CpCDPK1/TgCDPK1 dual inhibitor (IC₅₀: 10 nM and 5.0 nM respectively). CpCDPK1/TgCDPK1-IN-1 also inhibits Abl and Src (IC₅₀: 75 nM and 65 nM respectively). CpCDPK1/TgCDPK1-IN-1 can be used for research of toxoplasmosis .

HY-B0357A

Diclazuril potassium R-64433 potassium	Antibiotic Parasite	Infection
Diclazuril (R-64433) potassium, a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril potassium can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-B0357R

Diclazuril (Standard) R-64433 (Standard)	Antibiotic Parasite Reference Standards	Infection
Diclazuril (Standard) is the analytical standard of Diclazuril. This product is intended for research and analytical applications. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-W654156

Diclazuril-13C3,15N2	Isotope-Labeled Compounds Parasite Antibiotic	Infection
Diclazuril- ¹³C₃, ¹⁵N ² is ¹³C and ¹⁵N labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-B1916R

Acetylspiramycin (Standard) Spiramycin B (Standard); Spiramycin II (Standard); Foromacidin B (Standard)	Reference Standards Antibiotic Bacterial Parasite	Infection
Acetylspiramycin (Standard) is the analytical standard of Acetylspiramycin. This product is intended for research and analytical applications. Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection[1][2][3][4].

HY-13832S2

Atovaquone-d5 Atavaquone-d₅	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-B0688R

Dapsone (Standard) 4,4′-Diaminodiphenyl sulfone (Standard); DDS (Standard)	Reference Standards Antibiotic Parasite Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-13832S3

cis-Atovaquone-d4 cis-Atavaquone-d₄	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-175648

Antiparasitic agent-28	Parasite	Infection
Antiparasitic agent-28 is an orally active, selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (TgcPheRS) with blood-brain barrier penetration. Antiparasitic agent-28 inhibits the growth of T. gondii tachyzoites (TgME49-Fluc strain) an (EC₅₀ = 1 nM) and T. gondii bradyzoites (Tg68nLuc strain) induced by alkaline (EC₅₀ = 3 nM) and glutamine-rich medium (EC₅₀ = 0.1 nM). Antiparasitic agent-28 demonstrates potent anti-toxoplasmosis efficacy in mice infected with TgME49-Fluc tachyzoites. Antiparasitic agent-28 can be used for the study of Toxoplasma gondii infection .

HY-120808

GSK2188764	Parasite	Infection
GSK2188764 is a Toxoplasma gondii rhoptry protein 18 (ROP18) inhibitor with reported IC₅₀ values of 7.49 μM against Toxoplasma gondii. GSK2188764 inhibits serine-threonine kinase activity of ROP18 in vitro.GSK2188764 can be used for the research of toxoplasmosis .

HY-183286

DHFR-IN-27	Dihydrofolate reductase (DHFR) Parasite	Infection
DHFR-IN-27 (Compound LA4) is an orally active DHFR inhibitor and antimalarial agent, with a K_i value of 1.71 nM against TgDHFR. DHFR-IN-27 reduces the parasitic load of Toxoplasma gondii in infected mice and prolongs the survival time of infected mice. DHFR-IN-27 exerts Antiparasitic effects against Toxoplasma gondii. DHFR-IN-27 can be used in the research of toxoplasmosis .

HY-W714214

Ethalfluralin	Herbicide Microtubule/Tubulin PI3K Akt Apoptosis Autophagy Reactive Oxygen Species (ROS) NF-κB p38 MAPK	Infection
Ethalfluralin is a dinitroaniline herbicide and microtubule inhibitor. Ethalfluralin blocks nuclear division and cytokinesis of parasites by inhibiting intranuclear spindle formation. Ethalfluralin activates the phosphorylation levels of NF-κB and P38 MAPK, inhibits the PI3K/AKT signaling pathway, impairs mitochondrial function, and induces apoptosis, endoplasmic reticulum stress, autophagy, and ROS production. Ethalfluralin is applicable to research related to toxoplasmosis .

HY-P11767

NCR247	Ferroptosis	Infection
NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and haem sequesterer. NCR247 forms 6:6 haem:NCR247 hexamers and higher-order complexes to render haem and bound iron biologically inaccessible, induces iron-starvation response in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity.NCR247 is critical for establishing nitrogen-fixing symbiosis between Sinorhizobium meliloti and Medicago truncatula, and is inactive against cytochrome haem.NCR247’s D-enantiomer binds and sequesters haem equivalently to its L-enantiomer.NCR247 can be used for the research of infections, periodontal disease, toxoplasmosis .

Cat. No.	Product Name	Target	Research Area

HY-P11767

NCR247	Ferroptosis	Infection
NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and haem sequesterer. NCR247 forms 6:6 haem:NCR247 hexamers and higher-order complexes to render haem and bound iron biologically inaccessible, induces iron-starvation response in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity.NCR247 is critical for establishing nitrogen-fixing symbiosis between Sinorhizobium meliloti and Medicago truncatula, and is inactive against cytochrome haem.NCR247’s D-enantiomer binds and sequesters haem equivalently to its L-enantiomer.NCR247 can be used for the research of infections, periodontal disease, toxoplasmosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1350A

Fusidic acid sodium salt 2 Publications Verification Sodium fusidate; SQ-16360	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Source Classification Cancer	Bacterial Antibiotic Interleukin Related
Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .

Cat. No.	Product Name	Chemical Structure

HY-B0357S

Diclazuril-d4
Diclazuril-d₄ is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-B0273S

Sulfadiazine-d4
Sulfadiazine-d₄ is a deuterium labeled Sulfadiazine. Sulfadiazine is a sulfonamide antibiotic used for the treatment of toxoplasmosis .

HY-13832S

Atovaquone-d4
Atovaquone-d₄ is the deuterium labeled Atovaquone. Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-W654156

Diclazuril-13C3,15N2
Diclazuril- ¹³C₃, ¹⁵N ² is ¹³C and ¹⁵N labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-13832S2

Atovaquone-d5
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-13832S3

cis-Atovaquone-d4
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

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