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Cat. No.: HY-175648

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Antiparasitic agent-28

Antiparasitic agent-28 is an orally active, selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (TgcPheRS) with blood-brain barrier penetration. Antiparasitic agent-28 inhibits the growth of T. gondii tachyzoites (TgME49-Fluc strain) an (EC₅₀ = 1 nM) and T. gondii bradyzoites (Tg68nLuc strain) induced by alkaline (EC₅₀ = 3 nM) and glutamine-rich medium (EC₅₀ = 0.1 nM). Antiparasitic agent-28 demonstrates potent anti-toxoplasmosis efficacy in mice infected with TgME49-Fluc tachyzoites. Antiparasitic agent-28 can be used for the study of Toxoplasma gondii infection.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₁N₃O₃
Molecular Weight:481.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Antiparasitic agent-28 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Parasite Isoforms :

In Vitro

Antiparasitic agent-28 (Compound 12) (72 h) potently inhibits the growth of Toxoplasma gondii tachyzoites (TgME49-Fluc strain) (EC₅₀ = 1 nM, EC₉₀ = 2 nM)^[1].
Antiparasitic agent-28 (96 h) effectively inhibits the growth of T. gondii bradyzoites (Tg68nLuc strain) induced by alkaline (EC₅₀ = 3 nM) and glutamine-rich medium (EC₅₀ = 0.1 nM)^[1].
Antiparasitic agent-28 exhibits low toxicity to human hepatic HepG2 cells (CC₅₀ = 0.99 μM, SI = CC₅₀/EC₅₀ = 1447) and human monocytic THP-1 cells (CC₅₀ = 0.25 μM, SI = 374)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Note	T_max	T_1/2	F
Mice^[1]	10 mg/kg	p.o.	solution-20% PEG 400, 10% Vitamin E TPGS, 70%	1 h	3.54 h	9.4 %
Mice^[1]	10 mg/kg	p.o.	75% PEG300, 25% D5W	3 h	/	5.3 %
Mice^[1]	2 mg/kg	i.v.	/	0.5 h	3.73 h	/
Mice^[1]	3 mg/kg	p.o.	/	0.5 h	15.5 h	9 %

In Vivo

Antiparasitic agent-28 (Compound 12) (3 mg/kg, p.o., twice daily, 7 days) prevents chronic infection and in immunocompetent C57/BL6 female mice infected with TgME49-Fluc tachyzoites^[1].
Antiparasitic agent-28 (3 mg/kg, p.o., twice daily, 14 days) significantly prolongs the survival time in interferon gamma receptor 1 knockout mice infected with TgME49-Fluc tachyzoites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57/BL6 female mice (6-8 weeks old) infected with 300 TgME49-Fluc tachyzoites via intraperitoneal injection^[1]
Dosage:

3 mg/kg
Administration:

p.o., twice daily, 7 days
Result:

Prevented chronic infection (no parasite outgrowth in brain homogenate).
Did not cause significant changes in plasma levels of liver and kidney function indicators (ALT, AST, BUN, creatinine).

Animal Model:

Interferon gamma receptor 1 knockout (Ifngr1^⁻/⁻) mice infected with 300 TgME49-Fluc tachyzoites via i.p. injection^[1]
Dosage:

3 mg/kg
Administration:

p.o., twice daily, 14 days
Result:

Prolonged the survival time (longer than that of the sulfadiazine-treated group).

Chemical Information

Molecular Weight 481.59
Formula C₃₀H₃₁N₃O₃
SMILES

O=C(N1C[C@]([C@@H](C2=CC=C(C#CC3=CC=CC=C3O)C=C2)CC4)([H])N4CCC1)NC5=CC=C(OC)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Uddin T, et al. Improved Bicyclic Pyrrolidine Analogues Inhibit Toxoplasma gondii Growth In Vitro and Cure Infection In Vivo. J Med Chem. 2025 Aug 28;68(16):17350-17363. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Antiparasitic agent-28

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antiparasitic agent-28 Related Classifications

HY-175648 Related Classifications