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  3. Fanotaprim

Fanotaprim 

Cat. No.: HY-137439
Handling Instructions

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim has the potential for the research of toxoplasmosis.

For research use only. We do not sell to patients.

Fanotaprim Chemical Structure

Fanotaprim Chemical Structure

CAS No. : 2120282-75-7

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Description

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim has the potential for the research of toxoplasmosis[1].

In Vitro

Fanotaprim shows parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1].
Fanotaprim shows ability to inhibit the growth of T. gondii strains in vitro with EC50s ranging 7.6~ 29.8 nM (GT1, ME49, CTG, RUB and VAND)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) shows highly effective in control of acute infection by highly virulent strains of T. gondii in the murine model[1].
Fanotaprim (1mg/kg; i.v; mouse) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1].
Fanotaprim (0.83 mg/kg; p.o; mouse) shows F, Cmax, Tmax, and AUC0-last of 47.3%, 178 ng/mL, 0.05 hours and 750 ng h/mL, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1female mice (murine model of acute toxoplasmosis)[1]
Dosage: 1-10 mg/kg
Administration: p.o.; daily; beginning on day 1 through day 7
Result: Mice were monitored for survival for 30 days within termittent IVIS monitoring. At doses of 10 mg/kg Fanotaprim, q.d. or b.i.d. for 7 days, yielded 100% survival for 30 days.
Molecular Weight

378.43

Formula

C₁₉H₂₂N₈O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Fanotaprim
Cat. No.:
HY-137439
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