Endochin
Based on 1 Customer Validation
Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis.
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- Pureté: 99.41%
- CAS No.: 354155-51-4
- Formule: C18H25NO2
- Masse moléculaire:287.40
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: Endochin
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Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
Inhibition of human cytochrome bc1 complex derived from HEK293 cell mitochondria using 50 uM decylubiquinol as substrate
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[PMID: 24720377] |
| HepG2 | IC50 |
>10 μM
Compound: Endochin
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Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
Cytotoxicity against human HepG2 cells after 24 hrs incubation by Alamar Blue assay
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[PMID: 24720377] |
| J774 | EC50 |
>34.8 μM
Compound: 1
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Cytotoxicity against mouse J774 cells
Cytotoxicity against mouse J774 cells
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[PMID: 20828199] |
Endochin inhibits cytochrome c reduction by the T. gondii cytochrome bc1 complex, with an IC50 of 8.2 nM[1].
Endochin inhibits T. gondii with an IC50 of 0.003 nM[1].
Endochin (Compound 1) inhibits multidrug resistant W2 and TM90-C2B isolates of Plasmodium falciparum, with IC50s of 8.59 and 46.6 nM respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 354155-51-4
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Appearance Solid
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Masse moléculaire 287.40
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Formule C18H25NO2
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Color White to off-white
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SMILES
O=C1C(CCCCCCC)=C(C)NC2=C1C=CC(OC)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41. [Content Brief]
[2]. Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Endochin Related Classifications
HY-13833 Related Classifications
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