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cyclic+dinucleotide

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By Targets:	Antibiotic (3) Apoptosis (3) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (2) Drug Derivative (1) Drug-Linker Conjugates for ADC (1) Fungal (1) IFNAR (2) Interleukin Related (1) NF-κB (3) Nucleoside Antimetabolite/Analog (1) Phosphodiesterase (PDE) (1) Phosphoramidites (1) Reactive Oxygen Species (ROS) (2) Ser/Thr Protease (1) Somatostatin Receptor (1) STING (17)
By Research Areas:	Cancer (16) Infection (6) Inflammation/Immunology (10) Neurological Disease (1)
Oligonucleotides:	Adenine (1) Phosphoramidites (1)

Inhibitors & Agonists

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6693

Valinomycin 5+ Cited Publications NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-145010

SN-011 Maximum Cited Publications 11 Publications Verification	STING	Inflammation/Immunology
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC₅₀ of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .

HY-130115A

IACS-8803 disodium 1 Publications Verification	STING	Cancer
IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy .

HY-141550

BPK-25	NF-κB	Inflammation/Immunology
BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP .

HY-139586

Ulevostinag MK-1454	STING	Cancer
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research .

HY-141514

MSA-2 dimer 1 Publications Verification	STING	Inflammation/Immunology Cancer
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .

HY-P1206

CH 275 1 Publications Verification	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-21545

5'-O-DMT-Bz-rA	Phosphoramidites Nucleoside Antimetabolite/Analog	Others
5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis .

HY-176809

Parent CDN	STING	Cancer
Parent CDN is a cyclic dinucleotide and a STING agonist. Parent CDN exhibits anti-tumor activity .

HY-130115

IACS-8803	STING	Cancer
IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy .

HY-141662

2',3'-cGAMP-C2-PPA	STING Drug-Linker Conjugates for ADC	Inflammation/Immunology Cancer
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases .

HY-148420

CDN-A	STING	Inflammation/Immunology
CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes .

HY-130115B

IACS-8803 diammonium 1 Publications Verification	STING	Cancer
IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy .

HY-155100

BI 7446	STING	Inflammation/Immunology Cancer
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research .

HY-134375

cAIMP Cyclic Adenosine-Inosine Monophosphate	NF-κB IFNAR	Inflammation/Immunology
cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC₅₀ of 6.4 μmol/L .

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Biochemical Assay Reagents	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-139586C

Ulevostinag (isomer 3) MK-1454 (isomer 3)	STING	Cancer
Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research .

HY-176810

CDN prodrug-1	STING	Cancer
CDN prodrug-1 (Compound 2) is a STING ligand. CDN prodrug-1 consists of a cyclic dinucleotide (CDN) and a dialanine peptide linker. CDN prodrug-1 can be cleaved following internalization into endolysosomes by cathepsins and subsequently release the parent CDN. CDN prodrug-1 can be used for synthesis nanoparticles for drug delivery research .

HY-169225A

PDIC-NN dimethanesulfonate PDIC-NS	STING Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response .

HY-178966

STING agonist-48	STING	Infection Inflammation/Immunology
STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC₅₀ = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases .

HY-172533

3′,5′-DiOA-dC	STING	Cancer
3’,5’-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG). 3’,5’-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3’,5’-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3’,5’-DiOA-dC also increases the levels of TNF-α and IFN-γ in murine melanoma model .

HY-156205

CdnP-IN-1	Phosphodiesterase (PDE)	Infection
CdnP-IN-1 (compound c82) is a potent and selective non-nucleotide *MTB CDN PDE (CdnP; Mycobacterium tuberculosis* cyclic dinucleotide phosphodiesterase) inhibitor with an IC₅₀** of 18 μM. CdnP-IN-1 does not inhibit the enzymatic activities of three other bacterial CDN PDEs (Yybt, RocR, and GBS-CdnP), a viral CDN PDE (poxin) or mammalian ENPP1 .

HY-169225

PDIC-NN PDIC-NS free base	STING Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
PDIC-NN (PDIC-NS free base) is a STING activator with anticancer activity. PDIC-NN promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN triggers ROS burst and causes serious damage to mitochondria. PDIC-NN induces cell apoptosis and inhibits DNA replication. PDIC-NN activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response .

HY-112880

c-(2'FdAMP-2'FdIMP)	Drug Derivative STING NF-κB IFNAR Interleukin Related	Infection Cancer
c-(2'FdAMP-2'FdIMP) (Compound 52),a derivative of cAIMP (HY-134375), is a cyclic dinucleotide (CDN). c-(2'FdAMP-2'FdIMP) is a STING activator and significantly induce STING-dependent IRF and NF-κB pathway signaling. c-(2'FdAMP-2'FdIMP) can be used for STING-based immunotherapy, such as cancers and infectious diseases research .

HY-P10672

SEI144	Biochemical Assay Reagents	Others
SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .

Cat. No.	Product Name	Target	Research Area

HY-N6693

Valinomycin 5+ Cited Publications NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .

HY-P1206

CH 275 1 Publications Verification	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-P4102

Cyclic PSAP peptide	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Biochemical Assay Reagents	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P3193

Cyclic nona-L-arginine TFA	Peptides	Others
Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P10672

SEI144	Biochemical Assay Reagents	Others
SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .

Valinomycin 5+ Cited Publications NSC 122023	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Apoptosis Antibiotic Autophagy Fungal
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

5'-O-DMT-Bz-rA		Phosphoramidites Adenine
5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis .

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cyclic+dinucleotide

Inhibitors & Agonists

Peptides

NaturalProducts

Oligonucleotides

Natural
Products