1. Immunology/Inflammation
  2. STING
  3. MSA-2 dimer

MSA-2 dimer 

Cat. No.: HY-141514
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MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide.

For research use only. We do not sell to patients.

MSA-2 dimer Chemical Structure

MSA-2 dimer Chemical Structure

CAS No. : 2377881-92-8

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Description

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1].

IC50 & Target

Kd: 145 μM (STING)[1]

In Vivo

MSA-2 (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1].
MSA-2 (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1].
MSA-2 (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors[1].
MSA-2 (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues [1].
MSA-2 (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 (10 μM and 33 μM; macrophages) induces IFN-β[1].
MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 tumor-bearing mice
Dosage: 60 mg/kg
Administration: P.o.; 50 days
Result: Inhibited tumor growth and prolonged overall survival.
Animal Model: C57BL6 mice
Dosage: 40 mg/kg
Administration: S.c.; 25 days
Result: Induced complete tumor regression.
Animal Model: C57BL6 mice
Dosage: 60 mg/kg
Administration: P.o.; 4 hours
Result: Increased proinflammatory cytokine (IFN-β) level in tumors.
Animal Model: C57BL6 mice
Dosage: 50 mg/kg
Administration: S.c.; 4 hours
Result: MSA-2 concentrations were observed in tumors than in plasma or other nontumor tissues.
Molecular Weight

568.66

Formula

C₂₉H₂₈O₈S₂

CAS No.
SMILES

O=C(CCC(C1=CC2=C(C=C(C(CCCC3=CC4=C(C=C3OC)SC(C(CCC(O)=O)=O)=C4)=C2)OC)S1)=O)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MSA-2 dimerSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSSelectiveOralNon-nucleotideTHP-1AntitumorImmunogenicDimerInhibitorinhibitorinhibit

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MSA-2 dimer
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HY-141514
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