BI 7446
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research.
For research use only. We do not sell to patients.
- CAS No.: 2767011-00-5
- Formula: C20H22FN9O10P2S2
- Molecular Weight:693.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BI 7446 (CDN13) (3 μM, 10 μM, 6 h) increases IRF3 and TBK1 phosphorylation in THP1 STING-wild type cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:wild type and STING-knock out THP1 cells
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Concentration:3 μM, 10 μM
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Incubation Time:6 h
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Result:Observed a dose dependent increase of IRF3 and TBK1 phosphorylation in THP1 wild type cells but not in THP1 STING knockout cells.
BI 7446 (0.25, 1, 4 μg for subcutaneous injection, once weekly) generates tumor regression and a long-term immunologic memory against autologous tumor re-challenge in EMT6 mouse breast cancer model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 BALB/c mouse tumor model [1]
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Dosage:4, 12, 36 μg
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Administration:Intravenous injection (i.v.)
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Result:Observed a high plasma clearance and a short elimination half-life.
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Animal Model:EMT6 mouse breast cancer model[1]
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Dosage:0.25, 1, 4 μg
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Administration:Subcutaneous injection (s.c.)
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Result:Observed dose-dependent tumor regression even at the lowest tested dose.
Impaired the growth of the EMT6 tumors.
Chemical Information
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CAS No. 2767011-00-5
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Molecular Weight 693.52
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Formula C20H22FN9O10P2S2
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SMILES
O[C@H]1[C@@H](O2)[C@H](N3C(C=NNC4=O)=C4N=C3)O[C@@H]1CO[P@](O[C@H]5[C@@H](F)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]5CO[P@]2(S)=O)(S)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BI 7446 Related Classifications
HY-155100 Related Classifications
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