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BPK-25 

Cat. No.: HY-141550
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BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP.

For research use only. We do not sell to patients.

BPK-25 Chemical Structure

BPK-25 Chemical Structure

CAS No. : 2305052-86-0

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Description

BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1].

In Vitro

BPK-25 (10 μM; 5 hours) inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP[1].
BPK-25 (10 μM; 24 hours) suppresses NF-κB activation blocks nuclear factor of activated T-cells (NFAT) activation, as measured by >50% reductions in IκBα phosphorylation[1].
BPK-25 (10 μM; 4 hours) also reduces NFATc2 expression in T cells[1].
BPK-25 (0.1, 1, 5, 10, 20 μM; 24 hours) promotes the striking and selective reduction of several proteins in the nucleosome remodeling and deacetylation (NuRD) complex in a concentration- and time-dependent manner. BPK-25 does not have corresponding changes in mRNA expression[1].
A non-electrophilic propanamide analog of BPK-25 (BPK-25-ctrl) does not suppress T cell activation or affect NuRD complex proteins in T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.84

Formula

C₂₁H₁₇ClN₄O₂

CAS No.
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BPK-25
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HY-141550
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