2',3'-cGAMP-C2-PPA
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 2586047-11-0
- Formula: C27H36N10O14P2S2
- Molecular Weight:850.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
STING[1]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2586047-11-0
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Molecular Weight 850.71
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Formula C27H36N10O14P2S2
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SMILES
OC(CCC(C)SSCC[C@H]1[C@]2([H])[C@@](N3C4=C(C(N=C(N4)N)=O)N=C3)([H])O[C@]1([H])COP(O)(O[C@]5([H])[C@@](O[C@](N6C7=NC=NC(N)=C7N=C6)([H])[C@@H]5O)([H])COP(O)(O2)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.
[2]. Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175. [Content Brief]
[3]. Zhang X, et al GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2',3'-cGAMP-C2-PPA Related Classifications
HY-141662 Related Classifications
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