1. GPCR/G Protein
    Neuronal Signaling
  2. Somatostatin Receptor
  3. CH 275

CH 275 

Cat. No.: HY-P1206
Handling Instructions

CH 275 is a potent and selective somatostatin receptor 1 (sst1) agonist and display IC50 values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst1, sst3, sst4, sst2 and sst5 respectively. CH 275 can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CH 275 Chemical Structure

CH 275 Chemical Structure

CAS No. : 174688-78-9

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Description

CH 275 is a potent and selective somatostatin receptor 1 (sst1) agonist and display IC50 values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst1, sst3, sst4, sst2 and sst5 respectively[1]. CH 275 can be used for the research of Alzheimer’s disease[2].

In Vitro

CH275 (100 nM) activates neprilysin activity, wheras treatment with cyclo-SRIF can complete this activation in vitro in primary neuron-based cell culture system, a mixture of wildtype hippocampal, cortical and striatal neuron[1].

In Vivo

CH275 (osmotic pump administration; 56 μM; two weeks) decreases the level of neprilysin/SRIF in the App knock-in mice[1].
CH275 directly injects into the Lmol layer of 2-month-old AppNL-G-Fmice for four months. AppNL-G-F mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects[1].

Molecular Weight

1485.77

Formula

C₇₄H₉₆N₁₄O₁₅S₂

CAS No.

174688-78-9

Sequence Shortening

CKFF-{D-Trp}-FTFTSC (Disulfide bridge:Cys1-Cys11)

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CH 275CH275CH-275Somatostatin ReceptorSSTRsSSTRSst Aβ plaqueneprilysinhippocampalcorticalstriatal neuronAlzheimer’s diseaseInhibitorinhibitorinhibit

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CH 275
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