2. Immunology/Inflammation
  3. STING
  4. IACS-8803

IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (IACS-8803 disodium and IACS-8803 diammonium) that retains the same biological activity.

For research use only. We do not sell to patients.

IACS-8803 Chemical Structure

IACS-8803 Chemical Structure

CAS No. : 2095690-70-1

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Description

IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy[1].

IC50 & Target

STING[1]
In Vivo

IACS-8803 shows a superior systemic anti-tumor response in the B16 murine model of melanoma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

692.53

Formula

C20H23FN10O9P2S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NC1=C(C2=NC=N1)N=CN2[C@@H]3O[C@H]4[C@H]([C@H]3O[P@](S)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C7=C(N=C6)C(N)=NC=N7)F)O[P@](S)(OC4)=O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 15 mg/mL (21.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4440 mL 7.2199 mL 14.4398 mL
5 mM 0.2888 mL 1.4440 mL 2.8880 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4440 mL 7.2199 mL 14.4398 mL 36.0995 mL
5 mM 0.2888 mL 1.4440 mL 2.8880 mL 7.2199 mL
10 mM 0.1444 mL 0.7220 mL 1.4440 mL 3.6100 mL
15 mM 0.0963 mL 0.4813 mL 0.9627 mL 2.4066 mL
20 mM 0.0722 mL 0.3610 mL 0.7220 mL 1.8050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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IACS-8803 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IACS-88032095690-70-1IACS8803IACS 8803STINGStimulator of Interferon GenesTMEM173MITAERISMPYSantitumorefficacyB16murinemelanomaInhibitorinhibitorinhibit

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