IACS-8803 disodium

Name: IACS-8803 disodium
Brand: MedChemExpress
SKU: HY-130115A
Rating: 4.5 (1 reviews)

Cat. No.: HY-130115A Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy.

For research use only. We do not sell to patients.

IACS-8803 disodium Chemical Structure

CAS No. : 2243079-36-7

Size	Price	Stock	Quantity
1 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 4800	Get quote	Estimated Time of Arrival: December 31
50 mg	USD 7800	Get quote	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of IACS-8803 disodium:

IACS-8803 diammonium In-stock
IACS-8803 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy^[1].

In Vivo

IACS-8803 (10 µg; intra-tumoral injection) shows superior antitumor activity in mice bearing bilateral B16-OVA melanomas^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

738.51

Formula

C₂₀H₂₃FN₁₀Na₂O₉P₂S₂

CAS No.

2243079-36-7

Appearance

Solid

Color

White to off-white

SMILES

NC1=C(C2=NC=N1)N=CN2[C@@H]3O[C@H]4[C@H]([C@H]3O[P@](S)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C7=C(N=C6)C(N)=NC=N7)F)O[P@](S)(OC4)=O)=O)O.[2Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 56.67 mg/mL (76.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3541 mL	6.7704 mL	13.5408 mL
5 mM	0.2708 mL	1.3541 mL	2.7082 mL
10 mM	0.1354 mL	0.6770 mL	1.3541 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (67.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (274 KB) SDS (0 KB)

COA (252 KB) HNMR (260 KB) CNMR (346 KB) LCMS (140 KB)

Handling Instructions (2659 KB)

References

[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3541 mL	6.7704 mL	13.5408 mL	33.8519 mL
	5 mM	0.2708 mL	1.3541 mL	2.7082 mL	6.7704 mL
	10 mM	0.1354 mL	0.6770 mL	1.3541 mL	3.3852 mL
	15 mM	0.0903 mL	0.4514 mL	0.9027 mL	2.2568 mL
	20 mM	0.0677 mL	0.3385 mL	0.6770 mL	1.6926 mL
	25 mM	0.0542 mL	0.2708 mL	0.5416 mL	1.3541 mL
	30 mM	0.0451 mL	0.2257 mL	0.4514 mL	1.1284 mL
	40 mM	0.0339 mL	0.1693 mL	0.3385 mL	0.8463 mL
	50 mM	0.0271 mL	0.1354 mL	0.2708 mL	0.6770 mL
	60 mM	0.0226 mL	0.1128 mL	0.2257 mL	0.5642 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.