49 Results for "

human calcitonin

" in MedChemExpress (MCE) Product Catalog:
Products (49)

49 Results for "human calcitonin" in MCE Product Catalog:

47
47 Publications Verification
Cat. No.: HY-10095
CAS No.: 204697-65-4
Purity:  99.83%
Synonyms: BIBN-4096; BIBN 4096BS
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP .
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47
47 Publications Verification
Cat. No.: HY-10095A
CAS No.: 586368-06-1
Purity:  99.11%
Synonyms: BIBN-4096 hydrochloride; BIBN4096BS hydrochloride
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP .
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6
6 Cited Publications
Cat. No.: HY-P1071
CAS No.: 90954-53-3
Synonyms: calcitonin gene-related peptide
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects .
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6
6 Cited Publications
Cat. No.: HY-P1071A
Synonyms: calcitonin gene-related peptide TFA
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects .
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4
4 Cited Publications
Cat. No.: HY-P1471
CAS No.: 159899-65-7
Synonyms: 22-52-Adrenomedullin (human)
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .
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2
2 Cited Publications
Cat. No.: HY-P1548
CAS No.: 101462-82-2
Synonyms: human β-CGRP; CGRP-II (human)
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .
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2
2 Cited Publications
Cat. No.: HY-32709
CAS No.: 781649-09-0
Synonyms: MK-0974
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.
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2
2 Cited Publications
Cat. No.: HY-P1014
CAS No.: 119911-68-1
Synonyms: human α-CGRP (8-37)
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

HCGRP-(8-37) (Human α-CGRP (8-37)) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects .
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2
2 Cited Publications
Cat. No.: HY-P1548A
Synonyms: human β-CGRP TFA; CGRP-II (human) TFA
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .
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1
1 Cited Publications
Cat. No.: HY-P9938
CAS No.: 1582205-90-0
Synonyms: AMG-334

Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Erenumab (AMG-334) is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene-related peptide (CGRP) receptor. Erenumab prevents the increase in dermal blood flow in cynomolgus monkeys. Erenumab can be used in the research of episodic migraine .
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1
1 Cited Publications
Cat. No.: HY-134992
CAS No.: 1337918-83-8
Purity:  99.54%
Synonyms: Zavegepant; BHV-3500
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Vazegepant (Zavegepant; BHV-3500) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 23 pM for human CGRP receptor and an EC50 of 880 pM for reversing CGRP-induced vasodilation in human intracranial arteries. Vazegepant can block CGRP-mediated vasodilation in the trigeminal vascular system and inhibit neuronal circuit sensitization. Vazegepant can be used in migraine-related research .
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1
1 Cited Publications
Cat. No.: HY-P4058
CAS No.: 83652-28-2
Synonyms: CGRP free acid
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Calcitonin gene-related peptide (CGRP) free acid is a 37-amino acid neuropeptide, which represents the deamidated form of α-CGRP (human) (HY-P1071). Calcitonin gene-related peptide free acid is produced in the central and peripheral nervous systems of rats, and localizes to specific sensory, integrative and motor neuron systems, including those involved in nociception/thermoreception, feeding behavior, olfaction and visceral motor functions .
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1
1 Cited Publications
Cat. No.: HY-P1072
CAS No.: 87403-73-4
Target:  

CGRP Receptor

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism .
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1
1 Cited Publications
Cat. No.: HY-132131
CAS No.: 1414976-20-7
Purity:  99.36%
Synonyms: Zavegepant hydrochloride; BHV-3500 hydrochloride
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Vazegepant (Zavegepant hydrochloride; BHV-3500 hydrochloride) hydrochloride is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 23 pM for human CGRP receptor and an EC50 of 880 pM for reversing CGRP-induced vasodilation in human intracranial arteries. Vazegepant hydrochloride can block CGRP-mediated vasodilation in the trigeminal vascular system and inhibit neuronal circuit sensitization. Vazegepant hydrochloride can be used in migraine-related research .
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Cat. No.: HY-P10798
CAS No.: 2883634-40-8
Synonyms: LY-3841136
Research Areas:  

Metabolic Disease

Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC50 23.9 pM and human AMY3R EC50 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium 2+ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .
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Cat. No.: HY-P2273
CAS No.: 21215-62-3
Target:  

CGRP Receptor

Research Areas:  

Metabolic Disease

Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research .
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Cat. No.: HY-12366
CAS No.: 1374248-77-7
Purity:  99.90%
Synonyms: MK-1602
Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .
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Cat. No.: HY-P11274A
Synonyms: Amycretin sodium; NN 9487 sodium
Research Areas:  

Metabolic Disease

Zenagamtide (Amycretin; NN 9487) sodium is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide sodium is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide sodium improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide sodium may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases .
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Cat. No.: HY-P99017
CAS No.: 1644539-04-7
Synonyms: ALD-403

Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Eptinezumab (ALD-403) is a human monoclonal antibody targeting the α and β subtypes of human calcitonin gene-related peptide (CGRP). Eptinezumab binds to the CGRP ligand and blocks its binding to endogenous CGRP receptors, thereby inhibiting receptor activation. Eptinezumab can be used in research related to migraine .
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Cat. No.: HY-P4093
CAS No.: 209323-98-8
Research Areas:  

Others

Cys-Penetratin is a cysteine-containing cell-penetrating peptide with sequence CRQIKIWFQNRRMKWKK. Cys-Penetratin can Cys-Penetratin can be used for the research for the research of drug delivery .
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