Cys-Penetratin
Based on 1 Customer Validation
Cys-Penetratin is a cysteine-containing cell-penetrating peptide with sequence CRQIKIWFQNRRMKWKK. Cys-Penetratin can Cys-Penetratin can be used for the research for the research of drug delivery.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.37%
- CAS. Nr.: 209323-98-8
- Formel: C107H173N35O21S2
- Molecular Weight:2349.87
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Speicherung:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
>100 μM
Compound: 9a
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Antiproliferative activity against human Caco2 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human Caco2 cells after 48 hrs by sulforhodamine B assay
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[PMID: 28495087] |
| HT-29 | IC50 |
>100 μM
Compound: 9a
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Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay
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[PMID: 28495087] |
| MKN-28 | IC50 |
>100 μM
Compound: 9a
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Antiproliferative activity against human MKN28 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MKN28 cells after 48 hrs by sulforhodamine B assay
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[PMID: 28495087] |
In Vitro
Cys-penetratin (Cys-penetratin-conjugated liposomes) significantly enhance the cellular uptake of salmon calcitonin in TR146 human buccal cells compared to control liposomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 209323-98-8
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Appearance Solid
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Molecular Weight 2349.87
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Formel C107H173N35O21S2
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Color White to off-white
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Sequence
Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys
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Sequence Shortening
CRQIKIWFQNRRMKWKK
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 100 mg/mL (42.56 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Keum T, et al. Examination of Effective Buccal Absorption of Salmon Calcitonin Using Cell-Penetrating Peptide-Conjugated Liposomal Drug Delivery System. Int J Nanomedicine. 2022;17:697-710. Published 2022 Feb 15. [Content Brief]
[2]. Sadowsky JD, et al. Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates. Bioconjug Chem. 2017;28(8):2086-2098. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4256 mL | 2.1278 mL | 4.2556 mL | 10.6389 mL |
| 5 mM | 0.0851 mL | 0.4256 mL | 0.8511 mL | 2.1278 mL | |
| 10 mM | 0.0426 mL | 0.2128 mL | 0.4256 mL | 1.0639 mL | |
| 15 mM | 0.0284 mL | 0.1419 mL | 0.2837 mL | 0.7093 mL | |
| 20 mM | 0.0213 mL | 0.1064 mL | 0.2128 mL | 0.5319 mL | |
| 25 mM | 0.0170 mL | 0.0851 mL | 0.1702 mL | 0.4256 mL | |
| 30 mM | 0.0142 mL | 0.0709 mL | 0.1419 mL | 0.3546 mL | |
| 40 mM | 0.0106 mL | 0.0532 mL | 0.1064 mL | 0.2660 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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