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Pathways Recommended: GPCR/G Protein Antibody-drug Conjugate/ADC Related
Results for "

immunoglobulin G antibodies

" in MedChemExpress (MCE) Product Catalog:

41

Inhibitors & Agonists

1

Biochemical Assay Reagents

45

Inhibitory Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99955
    Rocatinlimab

    AMG 451; KHK4083

    		 Orexin Receptor (OX Receptor) Infection Inflammation/Immunology
    Rocatinlimab (AMG 451) (KHK4083) is a fully human immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) .
    Rocatinlimab
  • HY-P99033
    Mosunetuzumab
    1 Publications Verification

    BTCT-4465A; RG-7828; RO7030816

    		 CD20 CD3 Inflammation/Immunology Cancer
    Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs) .
    Mosunetuzumab
  • HY-P9920A
    Ramucirumab (anti-VEGFR)
    1 Publications Verification

    		 VEGFR Cancer
    Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .
    Ramucirumab (anti-VEGFR)
  • HY-P99550
    Tozorakimab
    1 Publications Verification

    MEDI-3506

    		 Interleukin Related Inflammation/Immunology
    Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease .
    Tozorakimab
  • HY-P99521
    Vibecotamab

    XmAb14045

    		 CD3 Inflammation/Immunology Cancer
    Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .
    Vibecotamab
  • HY-P990047
    Maridebart

    AMG133 antibody

    		 ADC Antibody GLP Receptor Metabolic Disease
    Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes .
    Maridebart
  • HY-P99036
    Nesvacumab

    		Tie Cardiovascular Disease Inflammation/Immunology Cancer
    Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .
    Nesvacumab
  • HY-P99114
    Sugemalimab

    		PD-1/PD-L1 Cancer
    Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research .
    Sugemalimab
  • HY-P990045
    Lixudebart

    ALE.F02

    		 Claudin Endocrinology
    Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis .
    Lixudebart
  • HY-P990032
    Belrestotug

    EOS-448; EOS884448; GSK4428859A

    		 Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer .
    Belrestotug
  • HY-P990089
    Patecibart

    Getagozumab; GMA-301

    		 Endothelin Receptor Cardiovascular Disease
    Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an endothelin receptor antagonist .
    Patecibart
  • HY-P990092
    Rolistobart

    		LILRB Transmembrane Glycoprotein Cancer
    Rolistobart is a humanized immunoglobulin G4-kappa, anti-LILRB4/CD85k monoclonal antibody. Rolistobart is an immunostimulant and antineoplastic .
    Rolistobart
  • HY-P991138
    Firsekibart

    Genakumab; GenSci048; Kinnazumab

    		 Interleukin Related Inflammation/Immunology
    Firsekibart is an immunoglobulin G4-λ2 monoclonal antibody targeting human interleukin 1β (IL-1β). Firsekibart is promising for research of inflammation-related diseases, such as rheumatoid arthritis and inflammatory bowel disease .
    Firsekibart
  • HY-P99938
    Pucotenlimab

    HX008

    		 PD-1/PD-L1 Cancer
    Pucotenlimab (HX008) is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody. Pucotenlimab can be used for the research of tumor .
    Pucotenlimab
  • HY-P990021
    Calpurbatug

    TRL1068

    		 Bacterial Others
    Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain .
    Calpurbatug
  • HY-163480
    PF-06835375

    		CXCR Inflammation/Immunology
    PF-06835375 is a selective, humanized CXCR5-targeting immunoglobulin G1 antibody. PF-06835375 depletes CXCR5-positive B cells, follicular helper T cells and circulating Tfh-like cells. PF-06835375 is applicable to research related to autoimmune diseases .
    PF-06835375
  • HY-P99551
    Tosatoxumab

    KBSA301; AR-301

    		 Antibiotic Bacterial Infection
    Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
    Tosatoxumab
  • HY-W145481A
    D-Galacto-D-mannan

    Carob galactomannan

    		 Sirtuin Inflammation/Immunology
    D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .
    D-Galacto-D-mannan
  • HY-P990048
    Muzastotug

    ADG126

    		 CTLA-4 Cancer
    Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic .
    Muzastotug
  • HY-P990714
    Obertamig

    		CD3 Inflammation/Immunology
    Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv) .
    Obertamig
  • HY-P99606
    Cirevetmab

    ZTS-00521426

    		 TGF-beta/Smad Inflammation/Immunology
    Cirevetmab (ZTS-00521426) is an immunoglobulin G2-kappa, Canis lupus familiaris TGFB1 caninized monoclonal antibody. Cirevetmab is an immunomodulator .
    Cirevetmab
  • HY-P990079
    Renvistobart

    BMS-986207; ONO-4686

    		 CD28 Inflammation/Immunology
    Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .
    Renvistobart
  • HY-P99698
    Lesabelimab

    LDP

    		 PD-1/PD-L1 Inflammation/Immunology Cancer
    Lesabelimab (LDP) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor .
    Lesabelimab
  • HY-P99607
    Clenoliximab

    IDEC-151

    		 HIV Inflammation/Immunology
    Clenoliximab (IDEC-151) is a macaque-human chimeric monoclonal antibody (immunoglobulin G4) specific for the CD4 molecule on the surface of T lymphocytes. Clenoliximab can be used for the research of rheumatoid arthritis .
    Clenoliximab
  • HY-P991706
    Nelvutamig

    		Phosphodiesterase (PDE) CD3 Cancer
    Nelvutamig is a humanized immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3) antibody targeting ENPP3/CD203c and CD3E. The corresponding isotype control is: Human immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3) .
    Nelvutamig
  • HY-P990020
    Eglatoprutug

    FSI-174

    		 c-Kit Others
    Eglatoprutug is an humanized immunoglobulin G1-kappa, anti-c-Kit monoclonal antibody .
    Eglatoprutug
  • HY-P990074
    Enlonstobart

    SG-001

    		 PD-1/PD-L1 Inflammation/Immunology
    Enlonstobart is a human immunoglobulin G4-kappa, anti-PDCD1 monoclonal antibody. Enlonstobart is an immunostimulant and antineoplastic .
    Enlonstobart
  • HY-147407
    Imbotolimod

    		EGFR Cancer
    Imbotolimod, immunoglobulin G1-kappa, is a humanized monoclonal antibody with anti-ERBB2 and antineoplastic activity. Imbotolimod is a derivative of telratolimod .
    Imbotolimod
  • HY-P991135
    Enzelkitug

    RO-7502175; RG-6411

    		 CCR Cancer
    Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .
    Enzelkitug
  • HY-P991153
    Potravitug

    		Virus Protease Infection
    Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation .
    Potravitug
  • HY-P991134
    Elegrobart

    		IGF-1R Inflammation/Immunology
    Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease .
    Elegrobart
  • HY-P991195
    SIM-0235

    SIM1811-03

    		 TNF Receptor Cancer
    SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) [1].
    SIM-0235
  • HY-P990080
    Sovipostobart

    BMS-986249

    		 CTLA-4 Cancer
    Sovipostobart is an immunoglobulin G1-kappa, anti-CTLA-4 human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic .
    Sovipostobart
  • HY-P991139
    Futermestotug

    		CTLA-4 Cancer
    Futermestotug is a humanized immunoglobulin G1-κ monoclonal antibody targeting human cytotoxic T-lymphocyte associated protein 4 (CTLA4). Futermestotug is promising for research of various malignant tumors .
    Futermestotug
  • HY-P991152
    Oturkibart

    QX-005N

    		 Interleukin Related Inflammation/Immunology
    Oturkibart is a humanized immunoglobulin G4-κ monoclonal antibody targeting the human interleukin 4 receptor (IL4R). Oturkibart is promising for research of inflammatory diseases, such as asthma and atopic dermatitis .
    Oturkibart
  • HY-P991137
    Exerenibart

    		Ser/Thr Protease Metabolic Disease
    Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency .
    Exerenibart
  • HY-W015405
    4-Methylphthalic anhydride

    		Human leukocyte immunoglobulin (Ig)-like receptors (LILR) Inflammation/Immunology
    4-Methylphthalic anhydride is an organic acid anhydride and an immunogen/sensitizer. 4-Methylphthalic anhydride induces the production of specific immunoglobulin E and immunoglobulin G antibodies. 4-Methylphthalic anhydride is used in studies of occupational allergy .
    4-Methylphthalic anhydride
  • HY-P992154
    Ricefidase

    KJ-103

    		 Human leukocyte immunoglobulin (Ig)-like receptors (LILR) Infection Inflammation/Immunology
    Ricefidase (KJ-103) is a recombinant human immunoglobulin G-degrading enzyme. Ricefidase efficiently cleaves human IgG at the hinge region. Ricefidase rapidly reduces IgG levels. Ricefidase has low immunogenicity and clears AAV neutralizing antibodies. Ricefidase is applicable to research related to desensitization of all IgG subclasses and improvement of the suitability of AAV-based gene therapy .
    Ricefidase
  • HY-P992105
    Corveldebart

    		ANGPTL Inflammation/Immunology
    Corveldebart is a monoclonal antibody of immunoglobulin G1-kappa that targets ANGPTL4. Corveldebart can be used as an immunomodulator .
    Corveldebart
  • HY-P992099
    Afivastobart

    AB598

    		 NTPDase Cancer
    Afivastobart (AB598) is a human ENTPD1 (CD39)-targeting monoclonal antibody with antineoplastic activity.Afivastobart binds as a monoclonal antibody to modulate Homo sapiens ENTPD1 activity.Afivastobart constitutes a glycoform alfa immunoglobulin G1-kappa monoclonal antibody .
    Afivastobart
  • HY-P992394
    JNJ-55920839

    CNTO-6358

    		 IFNAR Inflammation/Immunology
    JNJ-55920839 (CNTO-6358) is a fully human immunoglobulin G1κ monoclonal antibody and a selective Interferon α/ω neutralizer, with a Kd value of 0.9-10.7 pM against hIFNα and a Kd of 1.44 pM against IFNω. JNJ-55920839 can be used in research related to systemic lupus erythematosus .
    JNJ-55920839

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