2. Immunology/Inflammation
  3. Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
  4. 4-Methylphthalic anhydride

4-Methylphthalic anhydride is an organic acid anhydride and an immunogen/sensitizer. 4-Methylphthalic anhydride induces the production of specific immunoglobulin E and immunoglobulin G antibodies. 4-Methylphthalic anhydride is used in studies of occupational allergy.

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4-Methylphthalic anhydride

4-Methylphthalic anhydride Chemical Structure

CAS No. : 19438-61-0

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Based on 1 publication(s) in Google Scholar

4-Methylphthalic anhydride Related Antibodies

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Description

4-Methylphthalic anhydride is an organic acid anhydride and an immunogen/sensitizer. 4-Methylphthalic anhydride induces the production of specific immunoglobulin E and immunoglobulin G antibodies. 4-Methylphthalic anhydride is used in studies of occupational allergy[1].

In Vitro

4-methylphthalic anhydride forms a conjugate with rat serum albumin at a hapten density of 26 mol/mol (UV method) and 27 mol/mol (TNBS method)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Methylphthalic anhydride Related Antibodies
In Vivo

4-Methylphthalic anhydride (0.1 mL of 0.2 M; intradermal; single injection split into two 0.05 mL portions) induces the highest median specific IgE (3200) and IgG (6400) titers in Brown Norway rats compared to other tested organic acid anhydrides via intradermal immunization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brown Norway (BN) (male, 100-150 g, acclimatized for 1 week before experimentation)[1]
Dosage: 0.1 mL of 0.2 M
Administration: intradermal; single injection split into two 0.05 mL portions
Result: Exhibited the highest specific IgE and IgG titers among all tested organic acid anhydrides.
Reached a median specific IgE titer of 3200, with a range of 3200-6400.
Reached a median specific IgG titer of 6400, with a range of 3200-6400.
Showed titers significantly higher than those induced by all other tested organic acid anhydrides (P<0.05).
Molecular Weight

162.14

Formula

C9H6O3
CAS No.
Appearance

Solid

SMILES

O=C1OC(=O)C2=CC(=CC=C12)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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4-Methylphthalic anhydride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methylphthalic anhydride19438-61-0Human leukocyte immunoglobulin (Ig)-like receptors (LILR)Human leukocyte immunoglobulin (Ig)-like receptorsLILRImmunoglobulin-like transcriptILTLIRMIRCD85immunogenanti-4-methylhexahydrophthalic anhydride IgEimmunoglobulin Erat serum albuminGPSAimmunoglobulin G antibodiesoccupational allergysensitizerBrown Norway ratsInhibitorinhibitorinhibit

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