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Results for "

neurokinin-1 (NK1) receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurokinin Receptor (47) Apoptosis (1) Bcl-2 Family (1) Cadherin (1) Caspase (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) Drug Metabolite (1) Endogenous Metabolite (7) Fluorescent Dye (1) Interleukin Related (2) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) p38 MAPK (2) Reference Standards (3) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (18) Endocrinology (7) Infection (2) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (39)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0201

Substance P Maximum Cited Publications 31 Publications Verification neurokinin P	Neurokinin Receptor Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, *NK1R*).

HY-16346

Netupitant 4 Publications Verification CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Netupitant (CID-6451149) is a highly potent, selective and orally active **neurokinin-1 (NK₁)** receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect .

HY-14751

Rolapitant SCH619734	Neurokinin Receptor	Neurological Disease
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .

HY-W011978

N-Acetyl-L-tryptophan	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-101249

L-732138	Neurokinin Receptor	Neurological Disease Cancer
L-732138 is a selective, potent and competitive **neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors*, and has > 1000-fold more potent than human NK-2 and NK-3 receptors*. L-732138 can reduce hyperalgesia and has antitumor action .

HY-P0061A

Vapreotide acetate 1 Publications Verification RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-16436

Rolapitant hydrochloride hydrate SCH619734 hydrochloride hydrate	Neurokinin Receptor	Neurological Disease Cancer
Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model .

HY-14406A

L-733060 hydrochloride 1 Publications Verification	Neurokinin Receptor	Neurological Disease Cancer
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) *receptor* antagonist. L-733060 hydrochloride mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 hydrochloride blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 hydrochloride reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 hydrochloride can be used for the study of chronic orofacial pain .

HY-P0061

Vapreotide 1 Publications Verification RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of **neurokinin-1 receptor, with K_i** of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-122347A

Orvepitant maleate GW823296 maleate	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated **neurokinin-1 receptor (NK-1) antagonist with a pK_i** of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment .

HY-B2078A

Eprazinone dihydrochloride	Neurokinin Receptor	Inflammation/Immunology
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a **neurokinin 1 receptor (NK1R)** ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .

HY-P0201A

Substance P TFA Maximum Cited Publications 31 Publications Verification neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Substance P TFA (Neurokinin P TFA) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, *NK1R*) .

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor (NK1-receptor, NK1R)** .

HY-14405A

Casopitant mesylate GW679769B	Neurokinin Receptor Cytochrome P450	Neurological Disease Cancer
Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active **neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of Substance P (HY-P0201). Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4**. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) .

HY-P1722

Spantide II 1 Publications Verification	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent **neurokinin-1 receptor (NK-1R)** antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis .

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Neurological Disease
Vofopitant dihydrochloride (GR 205171A) is a blood-brain barrier-permeable NK1 receptor inhibitor with a pKi of 9.02 in mice. Vofopitant dihydrochloride blocks vomiting-related responses and inhibits pseudoptyalism. Vofopitant dihydrochloride exerts anxiolytic effects, regulates 5-HT receptor function and increases central 5-HT release. Vofopitant dihydrochloride improves hyperarousal symptoms of post-traumatic stress disorder. Vofopitant dihydrochloride can be used in research related to depression, anxiety, vomiting and postoperative nausea and vomiting .

HY-18006

NKP608 1 Publications Verification	Neurokinin Receptor Wnt Bcl-2 Family β-catenin Cyclin G-associated Kinase (GAK) VEGFR Caspase Cadherin Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
NKP608 is a non-peptidic derivative of 4-aminopiperidine, a highly selective, orally active, **neurokinin-1 (NK₁)** receptor antagonist with IC₅₀ of 2.6 nM. NKP608 is active both in vitro and in vivo, showing extremely low affinity for NK₂, NK₃ receptors. NKP608 exerts its effects by blocking the NK₁ receptor, regulate cell proliferation and apoptosis, affect neurotransmitter functions and gastric mucosal repair mechanisms, and suppress the Wnt/β-catenin pathway in antitumor research. NKP608 is applicable to research related to various diseases, including cough, anxiety disorders, depression, gastric mucosal injury, and colorectal cancer .

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist .

HY-P0201AF

Substance P, FAM-labeled TFA	Fluorescent Dye Endogenous Metabolite	Cancer
Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor of Substance P is neurokinin 1 receptor (NK1R) .

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on **neurokinin 1 receptor** (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

HY-19665

Lanepitant LY303870	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to *NK-1* receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis .

HY-12114

Serlopitant VPD-737; MK-0594	Neurokinin Receptor	Neurological Disease Endocrinology
Serlopitant is a selective **Neurokinin-1 (NK-1)** receptor antagonist.

HY-178269

SCH-720881	Drug Metabolite Neurokinin Receptor	Neurological Disease
SCH-720881 is the active metabolite of Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation .

HY-10050

CJ-17493	Neurokinin Receptor	Neurological Disease
CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a K_i of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca ²⁺ channels (IC₅₀ = 164 nM) and site 2 of sodium channels (IC₅₀ = 48 nM). CJ-17493 can be used for the study of neurological diseases .

HY-14406

L-733060	Neurokinin Receptor	Neurological Disease Cancer
L-733060 is a selective neurokinin-1 (NK-1) *receptor* antagonist. L-733060 mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 can be used for the study of chronic orofacial pain .

HY-P0061B

Vapreotide diacetate RC160 diacetate; BMY 41606 diacetate	Neurokinin Receptor	Cancer
Vapreotide diacetate is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P0255

Physalaemin	Neurokinin Receptor	Neurological Disease Endocrinology
Physalaemin, a non-mammalian tachykinin, binds selectively to *neurokinin-1* (NK1) *receptor* with high affinity.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin **neurokinin 1 (NK1)** receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-W011978S

N-Acetyl-L-tryptophan-d3	Isotope-Labeled Compounds Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
N-Acetyl-L-tryptophan-d₃ is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-122347

Orvepitant GW823296	Neurokinin Receptor	Neurological Disease Cancer
Orvepitant (GW823296) is potent, selective, orally active and well-tolerated **neurokinin-1 receptor (NK-1) antagonist with a pK_i** of 10.2 for human neurokinin-1 receptor. Orvepitant can across the blood-brain barrier. Orvepitant has the potential for depressive disorder and chronic refractory cough (CRC) treatment .

HY-12144

CP-99994	Neurokinin Receptor p38 MAPK	Neurological Disease
CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a K_i of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity .

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Neurological Disease
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent **neurokinin-1 (NK1)** receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-106982

Ezlopitant CJ-11,974	Neurokinin Receptor	Neurological Disease Metabolic Disease
Ezlopitant (CJ-11,974) is a selective, non-peptidic **neurokinin-1 (NK-1)-receptor** antagonist. Ezlopitant inhibits both acute and delayed emetic reactions induced by Cisplatin (HY-17394) in ferrets via acting on NK1 receptors in the central nervous system. Ezlopitant has the potential for pain, chemotherapy-induced emesis and irritable bowel syndrome research .

HY-172514

(1R,2S,3R)-Aprepitant	Neurokinin Receptor	Cancer
(1R,2S,3R)-Aprepitant (Compound ent-4) is a competitive human neurokinin-1 (NK-1) receptor antagonist. (1R,2S,3R)-Aprepitant is promising for research of cancers and postoperative nausea and vomiting .

HY-16346R

Netupitant (Standard) CID 6451149 (Standard)	Reference Standards Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant (Standard) is the analytical standard of Netupitant. This product is intended for research and analytical applications. Netupitant (CID-6451149) is a highly potent, selective and orally active **neurokinin-1 (NK₁)** receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect .

HY-116620

Benzomalvin C	Neurokinin Receptor	Infection
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

HY-159842

Fosrolapitant	Neurokinin Receptor	Neurological Disease
Fosrolapitant is a **neurokinin 1 (NK1) receptor** antagonist .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin **neurokinin 1 (NK1)** receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

HY-118378

ZD6021	Neurokinin Receptor	Neurological Disease Endocrinology
ZD6021 is an orally active **Neurokinin 1 Receptor antagonist, with K_i values of 0.12 nM for NK1 and 0.62 nM for NK2. At a concentration of 100 nM, ZD6021 has a pK_B value of 8.9 for human pulmonary artery NK1** receptors, and a pK_B value of 7.3 for human bronchial NK2 receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED₅₀ of 0.5 mg/kg, and also decreases NK2 mediated bronchoconstriction, with an ED₅₀ of 13 mg/kg .

HY-14751A

Rolapitant hydrochloride SCH619734 hydrochloride	Neurokinin Receptor	Neurological Disease Cancer
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model .

HY-12145

CP-99994 hydrochloride	Endogenous Metabolite Neurokinin Receptor p38 MAPK	Neurological Disease
CP-99994 hydrochloride is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a K_i of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity .

HY-14751R

Rolapitant (Standard) SCH619734 (Standard)	Reference Standards Neurokinin Receptor	Neurological Disease Cancer
Rolapitant (Standard) is the analytical standard of Rolapitant. This product is intended for research and analytical applications. Rolapitant (SCH619734) is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .

HY-14405

Casopitant GW679769	Neurokinin Receptor Cytochrome P450	Neurological Disease
Casopitant (GW679769) is a potent, selective, brain-penetrant and orally active neurokinin 1 (NK₁) receptor antagonist. Casopitant antagonizes the emetic effects of Substance P (HY-P0201). Casopitant is also a substrate and weak to moderate inhibitor of CYP3A4. Casopitant is indicated for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) .

HY-101249R

L-732138 (Standard)	Neurokinin Receptor Reference Standards	Neurological Disease Cancer
L-732138 (Standard) is the analytical standard of L-732138 (HY-101249). This product is intended for research and analytical applications. L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC50 of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action .

HY-123497

R116031	Neurokinin Receptor	Neurological Disease
R116031 is a selective **Neurokinin-1 (NK-1) receptor antagonist with a K_i** of 0.45 nM for human NK-1 receptor. R116031 inhibits Substance P (HY-P0201)-induced peripheral effects (skin reactions and plasma extravasation in guinea pigs) and a central effect (thumping in gerbils).R116031 labeled with ³H significantly accumulate in the striatum, olfactory tubercule, olfactory bulb and locus coeruleus in gerbils models. R116031 can be used as a positron emission tomography (PET) ligand for PET imaging .

HY-19203

CGP-49823	Neurokinin Receptor	Neurological Disease
CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 *receptor*). CGP-49823‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research .

Cat. No.	Product Name	Target	Research Area

HY-P0201

Substance P Maximum Cited Publications 31 Publications Verification neurokinin P	Neurokinin Receptor Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, *NK1R*).

HY-P0061A

Vapreotide acetate 1 Publications Verification RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P0061

Vapreotide 1 Publications Verification RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of **neurokinin-1 receptor, with K_i** of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P0201A

Substance P TFA Maximum Cited Publications 31 Publications Verification neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Substance P TFA (Neurokinin P TFA) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, *NK1R*) .

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor (NK1-receptor, NK1R)** .

HY-P1722

Spantide II 1 Publications Verification	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent **neurokinin-1 receptor (NK-1R)** antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis .

HY-P0201AF

Substance P, FAM-labeled TFA	Fluorescent Dye Endogenous Metabolite	Cancer
Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor of Substance P is neurokinin 1 receptor (NK1R) .

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on **neurokinin 1 receptor** (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation .

HY-P0061B

Vapreotide diacetate RC160 diacetate; BMY 41606 diacetate	Neurokinin Receptor	Cancer
Vapreotide diacetate is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin **neurokinin 1 (NK1)** receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin **neurokinin 1 (NK1)** receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0201

Substance P Maximum Cited Publications 31 Publications Verification neurokinin P	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, *NK1R*).

HY-W011978

N-Acetyl-L-tryptophan	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-P0255

Physalaemin	Animals Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Endocrinology Source Classification	Neurokinin Receptor
Physalaemin, a non-mammalian tachykinin, binds selectively to *neurokinin-1* (NK1) *receptor* with high affinity.

HY-119552

Acetylaszonalenin LL-S490β	Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Neurokinin Receptor
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent **neurokinin-1 (NK1)** receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-116620

Benzomalvin C	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Neurokinin Receptor
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

Cat. No.	Product Name	Chemical Structure

HY-16346S

Netupitant-d6
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist .

HY-W011978S

N-Acetyl-L-tryptophan-d3

N-Acetyl-L-tryptophan-d₃ is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

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HY-P81073

	NK1R Antibody neurokinin 1; neurokinin 1 receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1; NK1-R; NK1R	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat, Guinea Pig
	NK1R Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NK1R.

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neurokinin-1 (NK1) receptor

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