Sesamin

Name: Sesamin
Brand: MedChemExpress
SKU: HY-N0121
Rating: 5.0 (11 reviews)

Cat. No.: HY-N0121 Purity: 99.85%: Data Sheet
COA

SDS
Handling Instructions
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Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.

For research use only. We do not sell to patients.

CAS No. : 607-80-7

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Sesamin:

(-)-Sesamin In-stock
Sesamin (Standard) In-stock
Sesamin-d₈ Get quote

11 Publications Citing Use of MCE Sesamin

Cell Proliferation/Viability Assay

Apoptosis Analysis

Flow Cytometry

In Vivo Efficacy Study

: Sesamin purchased from MedChemExpress. Usage Cited in: J Orthop Surg Res. 2023 Jul 31;18(1):552. [Abstract]; Sesamin (1, 4, 7 μM) treatment delayed LPS-induced apoptosis in ATDC5 cells.

: Sesamin purchased from MedChemExpress. Usage Cited in: J Orthop Surg Res. 2023 Jul 31;18(1):552. [Abstract]; Sesamin (1, 4, 7 μM) treatment promoted LPS-induced proliferation in ATDC5 cells and decreased the rate of EdU-positive cells by flow cytometry.

: Sesamin purchased from MedChemExpress. Usage Cited in: Chem Biol Drug Des. 2022 Jan;99(1):118-125. [Abstract]; Four ESCC cell lines were incubated with indicated concentrations of Sesamin overnight, and subjected to CCK-8 assay.

: Sesamin purchased from MedChemExpress. Usage Cited in: Chem Biol Drug Des. 2022 Jan;99(1):118-125. [Abstract]; ECA109 and KYSE150 cells were incubated with Sesamin (0, 10, 20, 40 μM) overnight, and the protein levels of TRIM44 and TLR4 were determined by Western blot assay.

: Sesamin purchased from MedChemExpress. Usage Cited in: Chem Biol Drug Des. 2022 Jan;99(1):118-125. [Abstract]; Tumor volumes were significantly decreased in Sesamin (100, 150 mg/kg, p.o.) treated groups.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

delta 5 desaturase^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Daoy	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human DaOY cells after 3 days by MTT assay Cytotoxicity against human DaOY cells after 3 days by MTT assay	[PMID: 21115251]
HeLa	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human HeLa cells after 3 days by MTT assay Cytotoxicity against human HeLa cells after 3 days by MTT assay	[PMID: 21115251]
HEp-2	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human Hep2 cells after 3 days by MTT assay Cytotoxicity against human Hep2 cells after 3 days by MTT assay	[PMID: 21115251]
HepG2	EC₅₀	>60 μM Compound: 4	Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay	[PMID: 22381047]
HepG2	IC₅₀	229 μM Compound: Sesamin	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31784199]
HepG2	IC₅₀	9.4 μM Compound: 4	Inhibition of TNFalpha-induced NFkappaB transcriptional activity in human HepG2 cells pretreated for 1 hr before TNFalpha challenge by luciferase reporter gene analysis Inhibition of TNFalpha-induced NFkappaB transcriptional activity in human HepG2 cells pretreated for 1 hr before TNFalpha challenge by luciferase reporter gene analysis	[PMID: 22381047]
KB	ED₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 521819]
MCF7	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 21115251]
Neutrophil	IC₅₀	1.38 μg/mL Compound: (+)-Episesamin	Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced elastase release Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced elastase release	[PMID: 19128011]
Neutrophil	IC₅₀	4.3 μg/mL Compound: (+)-Episesamin	Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation	[PMID: 19128011]
Neutrophil	IC₅₀	90.23 μM Compound: 7, (-)-sesamin	Inhibition of fMLP-induced superoxide production in human neutrophils Inhibition of fMLP-induced superoxide production in human neutrophils	[PMID: 17559265]
SH-SY5Y	IC₅₀	229 μM Compound: Sesamin	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 31784199]

In Vitro

Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.35

Formula

C₂₀H₁₈O₆

CAS No.

607-80-7

Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]12[C@@H](C3=CC=C(OCO4)C4=C3)OC[C@]1([H])[C@@H](C5=CC=C(OCO6)C6=C5)OC2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (282.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8221 mL	14.1103 mL	28.2207 mL
5 mM	0.5644 mL	2.8221 mL	5.6441 mL
10 mM	0.2822 mL	1.4110 mL	2.8221 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (275 KB) SDS (394 KB)

COA (250 KB) RP-HPLC (221 KB)

Handling Instructions (2659 KB)

References

[1]. Cheng FC, et al. Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. Int J Biomed Sci. 2006 Sep;2(3):284-8. [Content Brief]

[2]. Shimizu S, et al. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acidbiosynthesis. Lipids. 1991 Jul;26(7):512-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8221 mL	14.1103 mL	28.2207 mL	70.5517 mL
	5 mM	0.5644 mL	2.8221 mL	5.6441 mL	14.1103 mL
	10 mM	0.2822 mL	1.4110 mL	2.8221 mL	7.0552 mL
	15 mM	0.1881 mL	0.9407 mL	1.8814 mL	4.7034 mL
	20 mM	0.1411 mL	0.7055 mL	1.4110 mL	3.5276 mL
	25 mM	0.1129 mL	0.5644 mL	1.1288 mL	2.8221 mL
	30 mM	0.0941 mL	0.4703 mL	0.9407 mL	2.3517 mL
	40 mM	0.0706 mL	0.3528 mL	0.7055 mL	1.7638 mL
	50 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.4110 mL
	60 mM	0.0470 mL	0.2352 mL	0.4703 mL	1.1759 mL
	80 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8819 mL
	100 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7055 mL

Sesamin Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sesamin607-80-7Stearoyl-CoA Desaturase (SCD)deltadesaturasepolyunsaturatedfattyacidbiosynthesisneuroprotectioncerbralischemiaInhibitorinhibitorinhibit

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Sesamin

Customer Review

Other Forms of Sesamin:

Sesamin Related Antibodies

11 Publications Citing Use of MCE Sesamin

Featured Recommendations

•Related Screening Libraries:

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•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Sesamin Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Sesamin Related Classifications

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