SKF 91488 dihydrochloride  (Synonyms: Homodimaprit dihydrochloride)

SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a K_i value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension^[1][2][3][4].

SKF 91488 (100 μM, 20 mins) eliminates the infection-induced airway hyperresponsiveness to histamine in Mycoplasma -infected pneumonia hamster tracheal segments^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SKF 91488 (20-100 μg, i.c.v.) increases mean arterial pressure (MAP) and heart rate (HR) in Wistar rats^[1].
SKF 91488 (10 μg, i.c.v., 5 mins before bleeding) does not affect the blood volume required to reduce MAP to 60 mmHg but significantly increases the blood volume required to reduce MAP to 40 mmHg and 20 mmHg in Wistar rats^[1].
SKF 91488 (10 μg, i.c.v.) significantly increases histamine concentrations in the hypothalamus and medulla oblongata in Wistar rats^[1].
SKF 91488 (10 mM, aerosolized inhalation, 90 breaths per administration, 15 mins before OA challenge) potentiates ovalbumin (OA)-induced bronchoconstriction in OA-sensitized Hartley guinea pigs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

248.22

C₇H₁₉Cl₂N₃S

68941-21-9

Solid

White to off-white

N=C(N)SCCCCN(C)C.Cl.Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Jochem J, et al. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44.  [Content Brief]

  [2]. Sekizawa K, et al. Histamine N-methyltransferase modulates histamine- and antigen-induced bronchoconstriction in guinea pigs in vivo. Am Rev Respir Dis. 1993 Jan;147(1):92-6.  [Content Brief]

  [3]. Tamaoki J, et al. Airway hyperresponsiveness to histamine in mycoplasmal infection: role of histamine N-methyltransferase. Eur J Pharmacol. 1998 Apr 24;347(2-3):257-60.  [Content Brief]

  [4]. Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9(5-6):455-60.  [Content Brief]