2. Anti-infection
  3. Bacterial Antibiotic
  4. Sparfloxacin

スパルフロキサシン  (Synonyms: Sparfloxacin)

製品番号: HY-B0308 純度: 99.93%
COA 取扱説明書 Technical Support

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.

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Sparfloxacin

スパルフロキサシン 構造式

CAS 番号 : 110871-86-8

容量 価格（税別） 在庫状況 数量
100 mg $25 在庫あり
500 mg $40 在庫あり
1 g $48 在庫あり
5 g $77 在庫あり
10 g $124 在庫あり
25 g $248 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of Sparfloxacin:

スパルフロキサシン 関連抗体

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Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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製品説明

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity[1].

IC50 & Target

Quinolone

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
88.8 μM
Compound: sparfloxacin
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
[PMID: 23812503]
HEK293 IC50
>250 μM
Compound: Sparfloxacin
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
>250 μM
Compound: Sparfloxacin
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
127.6 μM
Compound: Sparfloxacin
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
21.7 μM
Compound: Sparfloxacin
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
33.6 μM
Compound: Sparfloxacin
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
46.9 μM
Compound: Sparfloxacin
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HeLa IC50
265 μM
Compound: Sparfloxacin
Inhibition of human HeLa cell proliferation
Inhibition of human HeLa cell proliferation
[PMID: 19595598]
NIH3T3 IC50
122 μM
Compound: Sparfloxacin
Inhibition of mouse NIH/3T3 cell proliferation by MTT assay
Inhibition of mouse NIH/3T3 cell proliferation by MTT assay
[PMID: 19595598]
V79 IC50
370 μg/mL
Compound: 20d
Clonogenic cytotoxicity against Chinese hamster V-79 cells
Clonogenic cytotoxicity against Chinese hamster V-79 cells
[PMID: 7473575]
体外実験

Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice[1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

スパルフロキサシン 関連抗体
分子量

392.40

分子式

C19H22F2N4O3
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CN(C2CC2)C3=C(C(N)=C(F)C(N4C[C@H](C)N[C@H](C)C4)=C3F)C1=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

0.1 M NaOH : 50 mg/mL (127.42 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 5 mg/mL (12.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5484 mL 12.7421 mL 25.4842 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL
10 mM 0.2548 mL 1.2742 mL 2.5484 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.93%

COA (250 KB) HNMR (255 KB) LCMS (92 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M NaOH 1 mM 2.5484 mL 12.7421 mL 25.4842 mL 63.7105 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL 12.7421 mL
10 mM 0.2548 mL 1.2742 mL 2.5484 mL 6.3711 mL
0.1 M NaOH 15 mM 0.1699 mL 0.8495 mL 1.6989 mL 4.2474 mL
20 mM 0.1274 mL 0.6371 mL 1.2742 mL 3.1855 mL
25 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
30 mM 0.0849 mL 0.4247 mL 0.8495 mL 2.1237 mL
40 mM 0.0637 mL 0.3186 mL 0.6371 mL 1.5928 mL
50 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
60 mM 0.0425 mL 0.2124 mL 0.4247 mL 1.0618 mL
80 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7964 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
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Sparfloxacin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sparfloxacin110871-86-8CI-978 AT-4140CI978CI 978AT4140AT 4140AT-4140BacterialAntibioticInhibitorinhibitorinhibit

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