2. Epigenetics Membrane Transporter/Ion Channel Neuronal Signaling
  3. Small Interfering RNA (siRNA) TRP Channel
  4. Tivanisiran

Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) mRNA.

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RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)

Tivanisiran Estructura química

No. CAS : 1848224-71-4

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Other Forms of Tivanisiran:

Tivanisiran Related Antibodies

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Ver todos los productos específicos de isoformas TRP Channel:

Ver todas las isoformas
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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Descripciòn

Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) mRNA[1].

In Vitro

In vitro transfection of tivanisiran was shown to produce a 50-60% decrease in TRPV1 mRNA levels[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tivanisiran Related Antibodies
Ensayo clínico
Peso molecular

12068.30 (AS: 5294.6 + SS: 6125.7)

No. CAS
Appearance

Solid

Color

White to off-white

Sequence

RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)
SMILES

[Tivanisiran]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación
Referencias
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Tivanisiran Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivanisiran1848224-71-4SYL1001SYL 1001SYL-1001Small Interfering RNA (siRNA)TRP ChannelTransient receptor potential channelsDryeyediseaseDEDTRPV1Inhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Tivanisiran
Cat. No.:
HY-132596
Cantidad:
MCE Japan Authorized Agent:

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