2. Epigenetics Neuronal Signaling Membrane Transporter/Ion Channel
  3. Small Interfering RNA (siRNA) TRP Channel
  4. Tivanisiran sodium

Tivanisiran sodium  (Synonyms: SYL1001 sodium)

Cat. No.: HY-132596A Purity: 96.85%
COA
SDS
Handling Instructions Technical Support

Tivanisiran sodium (SYL1001 sodium) is a small interfering RNA (siRNA) targeting TRPV1 . Tivanisiran sodium induces the degradation of TRPV1 mRNA, thereby inhibiting protein synthesis. Tivanisiran sodium alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran sodium is applicable to research related to dry eye disease.

For research use only. We do not sell to patients.

RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1), sodium salt

Tivanisiran sodium Chemical Structure

CAS No. : 1848239-71-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Tivanisiran sodium:

Tivanisiran sodium Related Antibodies

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View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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Description

Tivanisiran sodium (SYL1001 sodium) is a small interfering RNA (siRNA) targeting TRPV1 . Tivanisiran sodium induces the degradation of TRPV1 mRNA, thereby inhibiting protein synthesis. Tivanisiran sodium alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran sodium is applicable to research related to dry eye disease[1][2].

IC50 & Target[1]

TRPV1

 

In Vitro

Tivanisiran sodium selectively silences TRPV1 in cell lines expressing TRPV subtypes, with an IC50 of 2.67 nM, and reduces TRPV1 mRNA levels by 50%-60%, with this effect peaking at 24-48 hours post-transfection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tivanisiran sodium Related Antibodies
In Vivo

Tivanisiran (multiple doses; once daily; administered consecutively for 4 days) sodium exhibits analgesic activity in a rabbit ocular pain model induced by Capsaicin (HY-10448)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White Rabbits[1]
Dosage: multiple doses
Administration: once daily; 4 consecutive days
Result: Produced palpebral opening responses similar to the reference standard Capsazepine at all evaluated time-points post-capsaicin challenge.
Molecular Weight

12068.3 (free acid)

Formula

C361H411N141O262Na36P36
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Tivanisiran (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 96.85%

SDS (252 KB)

COA (243 KB) LCMS (304 KB)

Handling Instructions (2242 KB)
References
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Tivanisiran sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivanisiran1848239-71-3SYL1001SYL 1001SYL-1001Small Interfering RNA (siRNA)TRP ChannelTransient receptor potential channelsocular hyperemiaTRPV4rabbit cell lineshuman cell linesTransient Receptor Potential Vanilloid 1TRPV1 mRNAtear qualityTRPV1capsaicin-induced ocular pain rabbit modeldry eye diseaseInhibitorinhibitorinhibit

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