Tivanisiran sodium
Based on 1 Customer Validation
Tivanisiran sodium (SYL1001 sodium) is a small interfering RNA (siRNA) targeting TRPV1 . Tivanisiran sodium induces the degradation of TRPV1 mRNA, thereby inhibiting protein synthesis. Tivanisiran sodium alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran sodium is applicable to research related to dry eye disease.
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- Pureté: 96.85%
- CAS No.: 1848239-71-3
- Formule: C361H411N141O262Na36P36
- Masse moléculaire:12068.3 (free acid)
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Activité biologique
Description
IC50 & Target
[1]|
TRPV1 |
In Vitro
Tivanisiran sodium selectively silences TRPV1 in cell lines expressing TRPV subtypes, with an IC50 of 2.67 nM, and reduces TRPV1 mRNA levels by 50%-60%, with this effect peaking at 24-48 hours post-transfection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White Rabbits[1]
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Dosage:multiple doses
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Administration:once daily; 4 consecutive days
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Result:Produced palpebral opening responses similar to the reference standard Capsazepine at all evaluated time-points post-capsaicin challenge.
Chemical Information
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CAS No. 1848239-71-3
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Appearance Solid
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Masse moléculaire 12068.3 (free acid)
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Formule C361H411N141O262Na36P36
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Color Off-white to light yellow
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SMILES
[Tivanisiran (sodium)]
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Synonyms
SYL1001 sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2242 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)