2. Epigenetics Membrane Transporter/Ion Channel Neuronal Signaling
  3. Small Interfering RNA (siRNA) TRP Channel
  4. Tivanisiran

Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1).

For research use only. We do not sell to patients.

RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)

Tivanisiran Chemical Structure

CAS No. : 1848224-71-4

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Tivanisiran Related Antibodies

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TRPC TRPM TRPV TRPA TRPML

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Description

Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1)[1].

In Vitro

In vitro transfection of tivanisiran was shown to produce a 50-60% decrease in TRPV1 mRNA levels[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tivanisiran Related Antibodies
Clinical Trial
Molecular Weight

12068.30 (AS: 5294.6 + SS: 6125.7)

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)
SMILES

[Tivanisiran]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (Infinity mM); Clear solution; Need ultrasonic

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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Tivanisiran Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivanisiran1848224-71-4SYL1001SYL 1001SYL-1001Small Interfering RNA (siRNA)TRP ChannelTransient receptor potential channelsDryeyediseaseDEDTRPV1Inhibitorinhibitorinhibit

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