Triprolidine hydrochloride

Name: Triprolidine hydrochloride
Brand: MedChemExpress
SKU: HY-B1808A
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-B1808A Reinheit: 99.76%: Data Sheet
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Triprolidine hydrochloride is an orally active histamine H1 antagonist. Triprolidine hydrochloride has the function of spinal cord motor and sensory block. Triprolidine hydrochloride can be used for the research of allergic rhinitis.

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Triprolidine hydrochloride Chemische Struktur

CAS. Nr. : 550-70-9

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5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
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Other Forms of Triprolidine hydrochloride:

(E/Z)-Triprolidine-d₈ hydrochloride In-stock
Triprolidine hydrochloride monohydrate In-stock
Triprolidine In-stock

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biologische Aktivität
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Beschreibung

IC₅₀ & Target^[1]

H₁ Receptor

In Vitro

Triprolidine hydrochloride (maturing human dendritic cells) can antagonist histamine H1 and decreases the expression of CD45^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Triprolidine hydrochloride (292.81-1467.20 μg/kg; i.p.; Male Sprague-Dawley rat) produces a dose-dependent effect of spinal motor and sensory block in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rat (300-350 g)^[2]
Dosage:	292.81, 488.02, 733.60, 1098.83 and 1467.20 μg/kg
Administration:	Intrathecal injection
Result:	Elicited a dose-dependent spinal block.

Molekulargewicht

314.85

Formel

C₁₉H₂₃ClN₂

CAS. Nr.

550-70-9

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Purity: 99.76%

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Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (295 KB) LCMS (111 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Szeberényi JB, et, al. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol Lett. 2001 Apr 2;76(3):175-82. [Content Brief]

[2]. Tzeng JI, et, al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661. [Content Brief]

[3]. Deal DL, Chandrasurin P, Shockcor J, Minick DJ, Findlay JW, McNulty MJ. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. 1992 Nov-Dec;20(6):920-7. [Content Brief]