1. Cytoskeleton
  2. Integrin
  3. αvβ1 integrin-IN-1 TFA

αvβ1 integrin-IN-1 TFA 

Cat. No.: HY-100445A Purity: 98.30%
Handling Instructions

αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects.

For research use only. We do not sell to patients.

αvβ1 integrin-IN-1 TFA Chemical Structure

αvβ1 integrin-IN-1 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of αvβ1 integrin-IN-1 TFA:

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Description

αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects[1].

IC50 & Target

IC50: 0.63 nM (αvβ1 integrin)[1]

In Vitro

αvβ1 integrin-IN-1 TFA (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1].

Molecular Weight

672.67

Formula

C₂₈H₃₅F₃N₆O₈S

SMILES

O=C(O)[[email protected]](CC1=CC=C(NC(CCCCNC(N)=N)=O)C=C1)NC([[email protected]]2N(S(=O)(C3=CC=CC=C3)=O)CCC2)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (371.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4866 mL 7.4331 mL 14.8661 mL
5 mM 0.2973 mL 1.4866 mL 2.9732 mL
10 mM 0.1487 mL 0.7433 mL 1.4866 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

αvβ1 integrin-IN-1Integrinαvβ1AntifibroticFibrosisInhibitorinhibitorinhibit

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Product name:
αvβ1 integrin-IN-1 TFA
Cat. No.:
HY-100445A
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