2. Search Result
Search Result
Results for "

Antifibrotic

" in MedChemExpress (MCE) Product Catalog:

64

Inhibitors & Agonists

10

Peptides

1

Inhibitory Antibodies

7

Natural
Products

6

Isotope-Labeled Compounds

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0136
    Taxifolin
    10+ Cited Publications

    (+)-Dihydroquercetin; (+)-Taxifolin

    		 Autophagy Tyrosinase Inflammation/Immunology
    Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    Taxifolin
  • HY-100445A
    αvβ1 integrin-IN-1 TFA
    3 Publications Verification

    		 Integrin Cardiovascular Disease Cancer
    αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects .
    αvβ1 integrin-IN-1 TFA
  • HY-N0136A
    (±)-Taxifolin

    (±)-Dihydroquercetin

    		 Autophagy Tyrosinase Inflammation/Immunology
    (±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    (±)-Taxifolin
  • HY-145555
    Bersiporocin

    DWN12088

    		 DNA/RNA Synthesis Inflammation/Immunology
    Bersiporocin is a prolyl-tRNA synthetase inhibitor. Bersiporocin has an IC50 of ≤100 nM for phosphoribosylpyrophosphate synthetase (PRS). Bersiporocin can be used for the research of antifibrotic .
    Bersiporocin
  • HY-162137
    Hepatoprotective agent-1

    		Apoptosis Inflammation/Immunology
    Hepatoprotective agent-1 (compound 1b) is a hepatoprotective agenrt. Hepatoprotective agent-1 shows anti-inflammatory, antiapoptotic and antifibrotic effects .
    Hepatoprotective agent-1
  • HY-N0136B
    (-)-Taxifolin

    (-)-Dihydroquercetin

    		 Tyrosinase Inflammation/Immunology
    (-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    (-)-Taxifolin
  • HY-119582
    Safironil

    		Others Inflammation/Immunology
    Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation .
    Safironil
  • HY-N0136S1
    (±)-Taxifolin-13C3

    (±)-Dihydroquercetin-13C3

    		 Autophagy Tyrosinase Inflammation/Immunology
    (±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .
    (±)-Taxifolin-13C3
  • HY-103070
    PythiDC

    		MMP Inflammation/Immunology
    PythiDC is a selective collagen prolyl 4-hydroxylase (CP4H1) inhibitor with an IC50 value of 4.0 μM. PythiDC can be used as a CP4H probe and also can be used for the development of a new class of antifibrotic and antimetastatic agents .
    PythiDC
  • HY-109083
    Cilofexor
    5+ Cited Publications

    GS-9674

    		 FXR Autophagy Inflammation/Immunology
    Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. Cilofexor has anti-inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research .
    Cilofexor
  • HY-156397
    HTH-02-006

    		AMPK Inflammation/Immunology Cancer
    HTH-02-006 is a NUAK2 inhibitor (IC50?=?126?nM). HTH-02-006 reduces levels of phosphorylated MYPT1 in HuCCT-1 cells. HTH-02-006 inhibits YAP-driven cell proliferation, hepatomegaly and tumorigenesis. HTH-02-006 also has antifibrotic protective effect .
    HTH-02-006
  • HY-111432
    CCG-232601

    		Ras Others
    CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma .
    CCG-232601
  • HY-147243
    Ansornitinib

    ANG-3070

    		 VEGFR PDGFR Cardiovascular Disease Inflammation/Immunology
    Ansornitinib is an orally active dual kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2). Ansornitinib can be used as an antifibrotic agent in lung, liver, kidney, and gastrointestinal fibrotic diseases .
    Ansornitinib
  • HY-137464A
    OATD-01
    1 Publications Verification

    		 Others Inflammation/Immunology
    OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research .
    OATD-01
  • HY-B0673S
    Pirfenidone-d5

    AMR69-d5

    		 TGF-beta/Smad CCR Inflammation/Immunology Cancer
    Pirfenidone-d5 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].
    Pirfenidone-d5
  • HY-100438
    Hydronidone

    Hydronidone is a pyridine derivative and an antifibrotic agent for hepatic fibrosis .
    Hydronidone
  • HY-162404
    Smad2/3-IN-2

    		STAT TGF-beta/Smad Inflammation/Immunology
    Smad2/3-IN-2 (Compound 3) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively .
    Smad2/3-IN-2
  • HY-162405
    Smad2/3-IN-1

    		STAT TGF-beta/Smad Inflammation/Immunology
    Smad2/3-IN-2 (Compound 3) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively .
    Smad2/3-IN-1
  • HY-N6928
    Mogroside III-E

    		Others Metabolic Disease Cancer
    Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, inhibits NO release, with anti-fibrotic activity .
    Mogroside III-E
  • HY-P4890
    Relaxin H3 (human)

    		RXFP Receptor Neurological Disease
    Relaxin H3 (human) is a kind of relaxin peptide. Relaxin H3 (human) exerts antifibrotic actions via RXFP1 .
    Relaxin H3 (human)
  • HY-P4890A
    Relaxin H3 (human) (TFA)

    		RXFP Receptor Neurological Disease
    Relaxin H3 (human) (TFA) is a kind of relaxin peptide. Relaxin H3 (human) (TFA) exerts antifibrotic actions via RXFP1 .
    Relaxin H3 (human) (TFA)
  • HY-101737
    24-Norursodeoxycholic acid

    Norucholic acid; nor-UDCA

    		 Others Inflammation/Immunology
    24-norursodeoxycholic acid (Norucholic acid) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.
    24-Norursodeoxycholic acid
  • HY-101473
    EMD527040

    		Integrin Inflammation/Immunology
    EMD527040 is a potent and highly selective αvβ6 antagonist with antifibrotic activities. EMD527040 can be used for carcinoma and liver fibrosis research .
    EMD527040
  • HY-15307
    Belumosudil
    20+ Cited Publications

    KD025; SLx-2119

    		 ROCK Inflammation/Immunology Cancer
    Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties .
    Belumosudil
  • HY-15307A
    Belumosudil mesylate
    20+ Cited Publications

    KD025 mesylate; SLx-2119 mesylate

    		 ROCK Inflammation/Immunology
    Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties .
    Belumosudil mesylate
  • HY-N1482
    Methyl palmitate

    Methyl palmitate, an acaricidal compound occurring in Lantana camara, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects .
    Methyl palmitate
  • HY-100445
    αvβ1 integrin-IN-1

    αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects .
    αvβ1 integrin-IN-1
  • HY-124646
    KIRA-7

    		IRE1 Inflammation/Immunology
    KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect .
    KIRA-7
  • HY-P0256
    Apamin
    3 Publications Verification

    Apamine

    		 Potassium Channel Neurological Disease Inflammation/Immunology
    Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
    Apamin
  • HY-148087
    AZD5462

    		RXFP Receptor Cardiovascular Disease
    AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties .
    AZD5462
  • HY-W803134
    (E/Z)-SIS3 free base

    		TGF-beta/Smad Inflammation/Immunology
    E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3 signaling pathway .
    (E/Z)-SIS3 free base
  • HY-113926
    BAY 60-2770

    		Guanylate Cyclase Cardiovascular Disease
    BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect .
    BAY 60-2770
  • HY-P0256A
    Apamin TFA
    3 Publications Verification

    Apamine TFA

    		 Potassium Channel Neurological Disease Inflammation/Immunology
    Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+-activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .
    Apamin TFA
  • HY-112606
    ML-290

    		RXFP Receptor Others
    ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM . ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.
    ML-290
  • HY-100775
    Fezagepras sodium

    Setogepram sodium; PBI-4050 sodium
    Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84 . Fezagepras sodium decreases renal, liver and pancreatic fibrosis . Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .
    Fezagepras sodium
  • HY-100775A
    Fezagepras

    Setogepram; PBI-4050

    		 Free Fatty Acid Receptor GPR84 Metabolic Disease Inflammation/Immunology
    Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84 . Fezagepras decreases renal, liver and pancreatic fibrosis . Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .
    Fezagepras
  • HY-P1931
    Antiflammin-1

    Uteroglobin(39-47)

    		 Interleukin Related Inflammation/Immunology
    Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury .
    Antiflammin-1
  • HY-137978
    Ezurpimtrostat

    GNS561

    		 Others Metabolic Disease Inflammation/Immunology Cancer
    Ezurpimtrostat (compound 2-2) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases (extracted from patent WO2020048694 A1) .
    Ezurpimtrostat
  • HY-136657
    SC-43
    2 Publications Verification

    		 Phosphatase STAT Apoptosis Cancer
    SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects .
    SC-43
  • HY-N1482S1
    Methyl palmitate-d31

    		Parasite Inflammation/Immunology
    Methyl palmitate-d31 is the deuterium labeled Methyl palmitate. Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects[1][2][3].
    Methyl palmitate-d31
  • HY-100495
    FT011
    1 Publications Verification

    		 MMP Inflammation/Immunology
    FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis . FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    FT011
  • HY-N1482S
    Methyl palmitate-13C16

    		Parasite Inflammation/Immunology
    Methyl palmitate- 13C16 is the 13C labeled Methyl palmitate. Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects[1][2][3].
    Methyl palmitate-13C16
  • HY-P99351
    Andecaliximab

    Anti-MMP9 Reference Antibody (andecaliximab)

    		 MMP Cancer
    Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF) .
    Andecaliximab
  • HY-P0266B
    N-Acetyl-Ser-Asp-Lys-Pro acetate

    Ac-SDKP acetate

    		 Angiotensin-converting Enzyme (ACE) Inflammation/Immunology
    N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .
    N-Acetyl-Ser-Asp-Lys-Pro acetate
  • HY-145855
    J-1063

    		TGF-β Receptor Inflammation/Immunology
    J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis .
    J-1063
  • HY-137978A
    Ezurpimtrostat hydrochloride

    GNS561 hydrochloride

    		 Others Metabolic Disease Inflammation/Immunology Cancer
    Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .
    Ezurpimtrostat hydrochloride
  • HY-B0673
    Pirfenidone
    Maximum Cited Publications
    39 Publications Verification

    AMR69

    		 TGF-beta/Smad CCR Inflammation/Immunology Cancer
    Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities .
    Pirfenidone
  • HY-N0664
    Aucubin
    5+ Cited Publications

    		 Bacterial Infection Neurological Disease Inflammation/Immunology Cancer
    Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
    Aucubin
  • HY-19149
    Ro24-7429

    Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects .
    Ro24-7429
  • HY-A0060
    Malotilate

    NKK 105

    		 Lipoxygenase Cancer
    Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
    Malotilate

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: