2. PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. PI3K ERK
  4. CXJ-2

CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy.

For research use only. We do not sell to patients.

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CXJ-2 Chemical Structure

CXJ-2 Chemical Structure

CAS No. : 2919976-92-2

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CXJ-2 Related Antibodies

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  • Biological Activity

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Description

CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy[1].

IC50 & Target

PI3K

 

ERK

 

In Vitro

CXJ-2 (10 μM , 24 h) decreases α-SMA expression in a dose-dependent manner in LX2 cells[1].
CXJ-2 (10 μM , 24 h) exhibits superior activity to inhibit LX2 cell proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CXJ-2 Related Antibodies
In Vivo

CXJ-2 (150 μg/kg, IP, daily for 3 weeks) remarkably diminishes hepatic fibrosis in mice[1].
CXJ-2 (0.1 mg/kg, SC, single dose) shows favorable pharmacokinetic properties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks, 20-24 g, CCl4-induced liver fibrosis model)[1]
Dosage: 150 μg/kg
Administration: IP, daily, for 3 weeks
Result: Significantly decreased the HYP (hydroxyproline) content in liver tissue. Decreased collagen deposition. Remarkably diminished hepatic fibrosis.
Animal Model: Sprague-Dawley rats[1]
Dosage: 0.1 mg/kg
Administration: SC, single dose (Pharmacokinetic Analysis)
Result: Showed favorable pharmacokinetic properties (Tmax=0.33 h, T1/2=0.46 h), and displayed enhanced clearance profiles. Displayed significantly higher serum stability with a half-life longer than 36 h.
Molecular Weight

1310.37

Formula

C55H87N15O22
CAS No.
Sequence

cyclo(Val-{Iva}-Gly-Ser-Pro-Ser-Ala-Gln-Glu-Glu-Ala-Ser-Pro-Ala)
Sequence Shortening

cyclo(V-{Iva}-GSPSAQEEASPA)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CXJ-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXJ-22919976-92-2CXJ2CXJ 2PI3KERKPhosphoinositide 3-kinaseExtracellular signal regulated kinasesLiver fibrosiscyclic peptideLX2 cellshydroxyprolineα-SMAcollagen depositionInhibitorinhibitorinhibit

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