BAY 60-2770
Based on 1 Customer Validation
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.
For research use only. We do not sell to patients.
- Purity : 98.15%
- CAS No.: 1027642-43-8
- Formula: C35H33F4NO5
- Molecular Weight:623.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Obese mice[2]
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Dosage:1 mg/kg
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Administration:p.o.; daily from the 10th to the 12th week
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Result:Ameliorates detrusor dysfunction in obese mice.
Chemical Information
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CAS No. 1027642-43-8
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Appearance Solid
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Molecular Weight 623.63
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Formula C35H33F4NO5
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(CN(CCCCC(O)=O)CCC2=CC(F)=CC=C2OCC3=CC=C(C4=CC=C(C(F)(F)F)C=C4)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 16.67 mg/mL (26.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Knorr A, et al. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80. [Content Brief]
[2]. Leiria LO, et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J Urol. 2014 Feb;191(2):539-47. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6035 mL | 8.0176 mL | 16.0351 mL | 40.0879 mL |
| 5 mM | 0.3207 mL | 1.6035 mL | 3.2070 mL | 8.0176 mL | |
| 10 mM | 0.1604 mL | 0.8018 mL | 1.6035 mL | 4.0088 mL | |
| 15 mM | 0.1069 mL | 0.5345 mL | 1.0690 mL | 2.6725 mL | |
| 20 mM | 0.0802 mL | 0.4009 mL | 0.8018 mL | 2.0044 mL | |
| 25 mM | 0.0641 mL | 0.3207 mL | 0.6414 mL | 1.6035 mL |
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