1. GPCR/G Protein
  2. Guanylate Cyclase
  3. BAY 60-2770

BAY 60-2770 

Cat. No.: HY-113926
Handling Instructions

BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.

For research use only. We do not sell to patients.

BAY 60-2770 Chemical Structure

BAY 60-2770 Chemical Structure

CAS No. : 1027642-43-8

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Description

BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2].

In Vivo

BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1].
BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2].

Animal Model: Obese mice[2]
Dosage: 1 mg/kg
Administration: p.o.; daily from the 10th to the 12th week
Result: Ameliorates detrusor dysfunction in obese mice.
Molecular Weight

623.63

Formula

C₃₅H₃₃F₄NO₅

CAS No.

1027642-43-8

SMILES

O=C(O)C1=CC=C(CN(CCCCC(O)=O)CCC2=CC(F)=CC=C2OCC3=CC=C(C4=CC=C(C(F)(F)F)C=C4)C=C3)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BAY 60-2770Guanylate Cyclaseoxide-independentfibroticoralfatbladderdysfunctionInhibitorinhibitorinhibit

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