1027642-43-8
1027642-43-8
Chemical Structure
BAY 60-2770
- CAS No.: 1027642-43-8
- Formula:C35H33F4NO5
- Molecular Weight:623.63
IUPAC Name: 4-(((4-carboxybutyl)(5-fluoro-2-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methoxy)phenethyl)amino)methyl)benzoic acid
InChIKey: CRQMDXFUKDWARU-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(CN(CCCCC(O)=O)CCC2=CC(F)=CC=C2OCC3=CC=C(C4=CC=C(C(F)(F)F)C=C4)C=C3)C=C1
Biological Activity: BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2].
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BAY 60-2770 | 98.15% | BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect. | ||||||||||||||||||||
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References
- [1]. Knorr A, et al. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80. [Content Brief]
- [2]. Leiria LO, et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J Urol. 2014 Feb;191(2):539-47. [Content Brief]
