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  4. Andecaliximab

Andecaliximab  (Synonyms: Anti-MMP9 Reference Antibody (andecaliximab))

Cat. No.: HY-P99351 Purity: ≥95.0%
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Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF).

For research use only. We do not sell to patients.

Andecaliximab Chemical Structure

Andecaliximab Chemical Structure

CAS No. : 1518996-49-0

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Andecaliximab Related Antibodies

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Description

Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF)[1][2].

In Vitro

Andecaliximab increases serum IL-7 levels[1].
Andecaliximab (50 μg/mL; 24 h) reduces phosphorylated SMAD2 (pSMAD2) of ABC-like cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Andecaliximab Related Antibodies
In Vivo

Andecaliximab improves T-cell receptor (TCR) diversity (decreased clonality) within tumor-infiltrating T-cell[1].
Andecaliximab (20 mg/kg; i.p. once) shows the antifibrotic efficacy in a humanized NSG mouse model of idiopathic pulmonary fibrosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized nonobese diabetic, SCID, IL-2 receptor g (NSG) mouse model of IPF[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg, once a week for once
Result: Decreased SMAD2 phosphorylation and increased surfactant protein C. Reduced MMP9+ cells, including MMP9+, CCR10+ and MMP9+CD45- and EpCAM+CCR10+ subpopulations.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Andecaliximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: ≥95.0%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Andecaliximab1518996-49-0Anti-MMP9 Reference Antibody (andecaliximab)MMPMatrix metalloproteinasesmAbIPFgastric adenocarcinomaIL-7SMAD2miceTCRInhibitorinhibitorinhibit

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