MMP9 - matrix metallopeptidase 9 Gene
Also Known as GELB; CLG4B; MMP-9; MANDP2
Species: Homo sapiens
About MMP9
This gene has 1 transcript (splice variant), 216 orthologues, 23 paralogues and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 144.9), lymph node (RPKM 49.8) and 3 other tissues.
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
MMP9 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004994.3 | NP_004985.2 | matrix metalloproteinase-9 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables endopeptidase activity |
EXP
EXP: Inferred from Experiment
|
9256427 | GOA |
| enables endopeptidase activity |
IDA
IDA: Inferred from direct assay
|
19022250 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
17937912 | GOA |
| enables metalloendopeptidase activity |
IDA
IDA: Inferred from direct assay
|
2551898 | GOA |
| enables metallopeptidase activity |
IDA
IDA: Inferred from direct assay
|
24236012 | GOA |
| enables peptidase activity |
IDA
IDA: Inferred from direct assay
|
23845380 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
2251898 | GOA |
| enables serine-type endopeptidase activity |
EXP
EXP: Inferred from Experiment
|
17428795 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
2551898 | GOA |
MMP9 Protein Structure
PG_binding_1: Putative peptidoglycan binding domain (40 - 94)
Peptidase_M10: Matrixin (115 - 444)
fn2: Fibronectin type II domain (230 - 271)
fn2: Fibronectin type II domain (288 - 329)
fn2: Fibronectin type II domain (347 - 388)
PT: PT repeat (472 - 506)
Hemopexin: Hemopexin (521 - 564)
Hemopexin: Hemopexin (568 - 605)
Hemopexin: Hemopexin (615 - 655)
Hemopexin: Hemopexin (663 - 701)
- 0
- 200
- 400
- 600
- 707 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
matrix metalloproteinase-9 |
|
|
MMP9 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MMP9 | P14780 | COL4A1 | Homo sapiens | P02462 | 33961781 | |
|
Intra
|
MMP9 | P14780 | COL4A2 | Homo sapiens | P08572 | 33961781 | |
|
Intra
|
MMP9 | P14780 | COL4A1 | Homo sapiens | P02462 | 28514442 | |
|
Intra
|
MMP9 | P14780 | COL6A1 | Homo sapiens | P12109 | 33961781 | |
|
Intra
|
MMP9 | P14780 | VCAN | Homo sapiens | P13611 | 23601700 | |
|
Intra
|
MMP9 | P14780 | COL4A2 | Homo sapiens | P08572 | 28514442 | |
|
Intra
|
MMP9 | P14780 | MMP9 | Homo sapiens | P14780 | 17937912 | |
|
Intra
|
MMP9 | P14780 | COL6A1 | Homo sapiens | P12109 | 28514442 | |
|
Intra
|
MMP9 | P14780 | TIMP1 | Homo sapiens | P01033 | 33961781 | |
|
Intra
|
MMP9 | P14780 | MEP1B | Homo sapiens | Q16820 | 23123160 | |
|
Intra
|
MMP9 | P14780 | TIMP1 | Homo sapiens | P01033 | 28514442 | |
|
Intra
|
MMP9 | P14780 | MMP9 | Homo sapiens | P14780 | 23601700 | |
|
Intra
|
MMP9 | P14780 | MEP1A | Homo sapiens | Q16819 | 23123160 | |
|
Intra
|
MMP9 | P14780 | COL5A1 | Homo sapiens | P20908 | 33961781 | |
|
Intra
|
MMP9 | P14780 | MMP9 | Homo sapiens | P14780 | 23601700 | |
|
Intra
|
MMP9 | P14780 | MMP9 | Homo sapiens | P14780 | 18077379 | |
|
Intra
|
MMP9 | P14780 | COL5A1 | Homo sapiens | P20908 | 28514442 | |
|
Intra
|
MMP9 | P14780 | SCUBE3 | Homo sapiens | Q8IX30 | 21441952 |
Recombinant MMP9 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P73300 | MMP-9 Protein, Human (HEK293) | NP_004985.2 (A20-D707) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78175 | MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) | P14780 (A20-D707) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78492 | MMP-9 Protein, Human (HEK293, His-Avi) | P14780 (A20-D707) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700572 | MMP-9 Protein, Human (P. pastoris, His) | P14780 (F107-D707) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P70145A | MMP-9 Protein, Human (HEK293, C-His) | P14780 (A19-D707) | ≥ 95%, as determined by reducing SDS-PAGE. |
MMP9 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80425 | MMP-9 Antibody (YA285) | WB, IHC-P, ICC/IF, FC, IF-Tissue | Human, Rat |
| HY-P80756 | MMP-9 Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P84101 | MMP-9 Antibody (YA3798) | IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P84101A | MMP-9 Antibody (YA3798)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P86656 | MMP-9 Antibody (YA6348) | WB, IHC-P, IHC-F, IF-Tissue | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Diverticulitis |
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| Angiokeratoma Of Fordyce |
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| Connective Tissue Disease |
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| Cutis Laxa |
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| Pneumothorax |
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| Myelitis |
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| Breast Cancer |
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| Fragile X Syndrome |
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| Conjunctivochalasis |
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| Brain Edema |
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| Carotid Stenosis |
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| Gastric Cancer |
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| Bronchitis |
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| Epidermolysis Bullosa |
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| Nervous System Disease |
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| Lipoprotein Quantitative Trait Locus |
|
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| Interstitial Lung Disease 2 |
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| Acute Myocardial Infarction |
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| Stroke, Ischemic |
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| Pelvic Inflammatory Disease |
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| Medulloblastoma |
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| Newcastle Disease |
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| Angiostrongyliasis |
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| Amyotrophic Lateral Sclerosis 1 |
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| Craniopharyngioma |
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| Esophageal Cancer |
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| Lung Cancer |
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| Aortic Dissection |
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| Osteonecrosis |
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| Hepatic Encephalopathy |
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| Lip And Oral Cavity Cancer |
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| Adenocarcinoma |
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| Root Resorption |
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| Osteogenic Sarcoma |
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| Appendicitis |
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| Hepatitis |
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| Tongue Disease |
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| Achalasia |
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| Filamentary Keratitis |
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| Prostate Cancer |
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| Bronchial Disease |
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| Bladder Cancer |
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| Pyoderma |
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| Gliosarcoma |
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| Pyelonephritis |
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| Glaucoma, Primary Open Angle |
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| Bronchiolitis Obliterans |
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| Rosacea |
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| Bone Cancer |
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| Myocardial Infarction |
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| Amaurosis Fugax |
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| Aortic Valve Disease 1 |
|
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| Bacterial Meningitis |
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| Dentin Caries |
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| Silicosis |
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| Peripheral Nervous System Disease |
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| Meningitis |
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| Hydronephrosis |
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| Punctate Epithelial Keratoconjunctivitis |
|
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| Squamous Cell Carcinoma |
|
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| Microvascular Complications Of Diabetes 1 |
|
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| Malignant Pleural Mesothelioma |
|
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| Cystic Fibrosis |
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| Vascular Disease |
|
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| Retinal Detachment |
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| Cerebrovascular Disease |
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| Schizophrenia |
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| Renal Cell Carcinoma, Nonpapillary |
|
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| Middle Ear Squamous Cell Carcinoma |
|
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| Vernal Keratoconjunctivitis |
|
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| Transitional Cell Carcinoma |
|
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| Cutis Laxa, Autosomal Dominant 2 |
|
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| Pancreatic Cancer |
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| Type 2 Diabetes Mellitus |
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| Scleritis |
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| Mycetoma |
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| Varicose Veins |
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| Recurrent Corneal Erosion |
|
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| Tetralogy Of Fallot |
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| Glioblastoma |
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| Osteoarthritis |
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| Chronic Meningitis |
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| Arthritis |
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| Pulmonary Emphysema |
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| Inflammatory Bowel Disease |
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| Neuritis |
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| Relapsing-Remitting Multiple Sclerosis |
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| Tongue Carcinoma |
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| Coronary Aneurysm |
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| Asthma |
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| Lymphangioleiomyomatosis |
|
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| Bone Squamous Cell Carcinoma |
|
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| Sick Building Syndrome |
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| Intracranial Berry Aneurysm |
|
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| Rheumatoid Arthritis |
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| Blepharitis |
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| Male Infertility |
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| Synovitis |
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| Lyme Disease |
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| Eyelid Disease |
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| Lung Disease |
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| Periapical Periodontitis |
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| Lacrimal Apparatus Disease |
|
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| Takayasu Arteritis |
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| Pelvic Organ Prolapse |
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| Cerebral Arterial Disease |
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| Skin Disease |
|
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| Squamous Cell Carcinoma, Head And Neck |
|
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| Keratitis, Hereditary |
|
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| Metaphyseal Anadysplasia 2 |
|
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| Aortic Aneurysm, Familial Thoracic 1 |
|
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| Intervertebral Disc Disease |
|
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| Prolapse Of Urethra |
|
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| Keratopathy |
|
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| Chromoblastomycosis |
|
|
| Colonic Benign Neoplasm |
|
|
| Pre-Eclampsia |
|
|
| Metaphyseal Anadysplasia |
|
|
| Cheilitis |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Oral Submucous Fibrosis |
|
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| Moyamoya Disease 1 |
|
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| Gastroenteritis |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
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| Heart Disease |
|
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| Gingivitis |
|
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| Multiple Sclerosis |
|
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| Pseudoxanthoma Elasticum |
|
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| Aortic Aneurysm |
|
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| Angiokeratoma Circumscriptum |
|
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| Osteoporosis |
|
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| Keratosis |
|
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| Spastic Entropion |
|
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| Intratubular Embryonal Carcinoma |
|
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| Heart Aneurysm |
|
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| Chordoma |
|
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| Corneal Ulcer |
|
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| Cholangiocarcinoma |
|
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| Pancreatic Adenocarcinoma |
|
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| Neuroblastoma |
|
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| Chronic Ulcer Of Skin |
|
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| Adenomyosis |
|
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| Ameloblastoma |
|
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| Ovarian Cancer |
|
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| Angiokeratoma Of Mibelli |
|
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| Hyperostosis |
|
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| Pulmonary Fibrosis |
|
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| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
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| Scoliosis |
|
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| Cholesteatoma Of Middle Ear |
|
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| Venous Insufficiency |
|
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| Fibrosarcoma |
|
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| Preterm Premature Rupture Of The Membranes |
|
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| Gingival Hypertrophy |
|
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| Benign Giant Cell Tumor |
|
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| Status Asthmaticus |
|
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| Macular Degeneration, Age-Related, 1 |
|
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| Spinal Cord Injury |
|
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| Sleep Apnea |
|
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| Aortic Disease |
|
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| Gingival Disease |
|
|
| Tropical Spastic Paraparesis |
|
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| Entropion |
|
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| Glioma |
|
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| Frontotemporal Dementia |
|
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| Eye Disease |
|
|
| Hypertensive Heart Disease |
|
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| Eosinophilic Meningitis |
|
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| Hemangioma |
|
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| Migraine With Or Without Aura 1 |
|
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| Hepatitis B |
|
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| High Grade Glioma |
|
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| Hypertension, Essential |
|
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| Melanoma |
|
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| Chorioamnionitis |
|
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| Aortic Aneurysm, Familial Abdominal, 1 |
|
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| Cerebral Artery Occlusion |
|
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| Autoimmune Disease |
|
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| Lung Cancer Susceptibility 3 |
|
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| Diabetes Mellitus |
|
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| Pituitary Apoplexy |
|
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| Myopia |
|
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| Bone Inflammation Disease |
|
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| Corneal Disease |
|
|
| Kawasaki Disease |
|
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| Infertility |
|
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| Meningioma, Familial |
|
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| Dilated Cardiomyopathy |
|
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| Endometrial Cancer |
|
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| Breast Adenocarcinoma |
|
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| Parotitis |
|
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| Leukemia, Acute Myeloid |
|
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| Colorectal Cancer |
|
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| Arteriosclerosis |
|
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| Cryptogenic Organizing Pneumonia |
|
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| Hepatocellular Carcinoma |
|
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| Thrombocytopenia |
|
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| Muscular Dystrophy |
|
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| Pyoderma Gangrenosum |
|
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| Conjunctivitis |
|
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| Dry Eye Syndrome |
|
|
| Carotid Artery Disease |
|
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| Inguinal Hernia |
|
|
| Periodontitis |
|
|
| Malaria |
|
|
| Cutis Laxa, Autosomal Dominant 3 |
|
|
| Decubitus Ulcer |
|
|
| Gallbladder Cancer |
|
|
| Pemphigoid |
|
|
| Hemiplegia |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Prolapse Of Lacrimal Gland |
|
|
| Myocarditis |
|
|
| Anaplastic Astrocytoma |
|
|
| Atherosclerosis Susceptibility |
|
|
| Keratoconus |
|
|
| Vein Disease |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | MMP9 | VGNC | VGNC:74903 |
| Bos taurus | MMP9 | VGNC | VGNC:31531 |
| Canis familiaris | MMP9 | VGNC | VGNC:43290 |
| Rattus norvegicus | MMP9 | RGD | RGD:621320 |
| Felis catus | MMP9 | VGNC | VGNC:68292 |
| Mus musculus | MMP9 | MGD | MGI:97011 |
| Others | MMP9 | NCBI |