5-HT3 antagonist 5

Name: 5-HT3 antagonist 5
Brand: MedChemExpress
SKU: HY-148038
Rating: 4.5 (0 reviews)

Cat. No.: HY-148038 Purity: 99.75%: Data Sheet
COA

SDS
Handling Instructions
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5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT₃ receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT₃ agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.

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5-HT3 antagonist 5 화학구조

CAS No. : 901599-43-7

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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•Related Screening Libraries:

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View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

5-HT₃ Receptor

In Vitro

5-HT3 antagonist 5 (compound 4c) exhibits 5-HT₃ receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT₃ agonist, 2-methyl-5-HT, with pA₂ value of 5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice (23 ± 2 g)^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration
Result:	Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.

분자량

279.29

화학식

C₁₆H₁₃N₃O₂

CAS No.

901599-43-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NC2=CC=CC=C2N=C1)NC3=CC=C(C=C3)OC

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 20.83 mg/mL (74.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5805 mL	17.9025 mL	35.8051 mL
5 mM	0.7161 mL	3.5805 mL	7.1610 mL
10 mM	0.3581 mL	1.7903 mL	3.5805 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.75%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (246 KB) HNMR (241 KB) LCMS (270 KB)

Handling Instructions (2659 KB)

References

[1]. Mahesh R, et al. Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6773-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5805 mL	17.9025 mL	35.8051 mL	89.5127 mL
	5 mM	0.7161 mL	3.5805 mL	7.1610 mL	17.9025 mL
	10 mM	0.3581 mL	1.7903 mL	3.5805 mL	8.9513 mL
	15 mM	0.2387 mL	1.1935 mL	2.3870 mL	5.9675 mL
	20 mM	0.1790 mL	0.8951 mL	1.7903 mL	4.4756 mL
	25 mM	0.1432 mL	0.7161 mL	1.4322 mL	3.5805 mL
	30 mM	0.1194 mL	0.5968 mL	1.1935 mL	2.9838 mL
	40 mM	0.0895 mL	0.4476 mL	0.8951 mL	2.2378 mL
	50 mM	0.0716 mL	0.3581 mL	0.7161 mL	1.7903 mL
	60 mM	0.0597 mL	0.2984 mL	0.5968 mL	1.4919 mL