2. GPCR/G Protein MAPK/ERK Pathway Apoptosis
  3. Ras Apoptosis
  4. CASIN

CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer.

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CAS 番号 : 425399-05-9

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 101 在庫あり
Solution
10 mM * 1 mL in DMSO USD 101 在庫あり
Solid
5 mg $92 在庫あり
10 mg $158 在庫あり
25 mg $317 在庫あり
50 mg $581 在庫あり
100 mg $950 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

CASIN 関連抗体

Top Publications Citing Use of Products

    CASIN purchased from MedChemExpress. Usage Cited in: iScience. 2025 Jul 14;28(7):112971.

    Representative stack images of skin vessels from wild-type mice treated with vehicle or 40 mg/kg CASIN intraperitoneally. Bottom of each stack includes the 2D AngioTool tracing of pixels in grayscale.

    CASIN purchased from MedChemExpress. Usage Cited in: iScience. 2025 Jul 14;28(7):112971.

    Representative H&E staining of C57B6 skin obtained from CASIN or vehicle-treated mice is shown. The thickness of the dermis was quantified and compared between vehicle and drug-treated mice.

    CASIN purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2022 Jun;12(6):e850.  [Abstract]

    PEMs were treated with RhoA inhibitor (CCG‐1423, 20 μM), Cdc42 inhibitor (CASIN, 20 μM), Rac1 inhibitor (1A‐116, 10 μM) or dual Cdc42/Rac1 inhibitor (MBQ‐167, 10 μM) for 1 h followed by Pam3CSK4 (0.5 μg/ml) and BSA or UGRP1 (0.5 μg/ml) treatment for 9 h to measure IL‐6 expression by ELISA.

    Ras アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    K-Ras H-Ras N-Ras Ras

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    • 純度とドキュメンテーション

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    製品説明

    CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer[1][2].

    IC50 & Target

    IC50: 2 μM (GTPase Cdc42)[1]
    体外実験

    CASIN (0-10 μM; 3 d) inhibits the growth of AMO-1, ARH-77, IM-9 , JJN-3, L-363, MOLP-8 and RPMI-8226/S cells[1].
    CASIN (0-10 μM; 16 h) inhibits melphalan induced FANCD2 mono-ubiquitination in LR5 cells but shows no effect to S cells[1].
    CASIN (5 μM; 2 d) increases cell apoptosis of bortezomib-resistant MM patient cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CASIN 関連抗体

    Cell Viability Assay[3]

    Cell Line: AMO-1, ARH-77, IM-9 , JJN-3, L-363, MOLP-8 and RPMI-8226/S cells
    Concentration: 0-10 μM
    Incubation Time: 3 days
    Result: Inhibited MM cell lines including AMO-1, ARH-77, IM-9 , JJN-3, L-363, MOLP-8 and RPMI-8226/S cells with GI50s vof 3.23, 4.31, 4.87, 2.56, 4.64, 4.67 and 3.97 μM, respectively.

    Western Blot Analysis[3]

    Cell Line: MM (S) and melphalan-resistant (LR5) MM cells
    Concentration: 5 μM
    Incubation Time: 16 hours
    Result: Abolished melphalan induced FANCD2 mono-ubiquitination and DNA damage in LR5, sensitized LR5 to melphalan-induced cell death by blocking FANCD2-mediated DNA damage repair.

    Apoptosis Analysis[3]

    Cell Line: Bortezomib-resistant MM patients cells
    Concentration: 5 μM
    Incubation Time: 2 days
    Result: 2-fold increased cell apoptosis in the cell derived from bortezomib-resistant MM patients.
    体内実験

    CASIN (20 mg/kg; i.p. 2 times a day) prolongs lifetime of mice with busulfan injection[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NSG mice with busulfan injection[3]
    Dosage: 20 mg/kg
    Administration: Intraperitoneal injection; 20 mg/kg 2 times a day
    Result: Significantly prolonged the lifespan of xenografts mice better than bortezomib, and showed a leading position when combined with bortezomib.
    分子量

    306.40

    分子式

    C20H22N2O
    CAS 番号
    Appearance

    Solid

    Color

    Yellow to brown

    SMILES

    OCCNC1C(NC2=C3C=C(C4=CC=CC=C4)C=C2)=C3CCC1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 31 mg/mL (101.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2637 mL 16.3185 mL 32.6371 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    濃度 （終了）

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    体積 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (6.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (6.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    g

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.89%

    COA (251 KB) LCMS (94 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.2637 mL 16.3185 mL 32.6371 mL 81.5927 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL 16.3185 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL 8.1593 mL
    15 mM 0.2176 mL 1.0879 mL 2.1758 mL 5.4395 mL
    20 mM 0.1632 mL 0.8159 mL 1.6319 mL 4.0796 mL
    25 mM 0.1305 mL 0.6527 mL 1.3055 mL 3.2637 mL
    30 mM 0.1088 mL 0.5440 mL 1.0879 mL 2.7198 mL
    40 mM 0.0816 mL 0.4080 mL 0.8159 mL 2.0398 mL
    50 mM 0.0653 mL 0.3264 mL 0.6527 mL 1.6319 mL
    60 mM 0.0544 mL 0.2720 mL 0.5440 mL 1.3599 mL
    80 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0199 mL
    100 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8159 mL
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    CASIN Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CASIN425399-05-9RasApoptosismultiple myelomadrug resistancebortezomibapoptosisInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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