425399-05-9
425399-05-9
Chemical Structure
CASIN
- CAS No.: 425399-05-9
- Formula:C20H22N2O
- Molecular Weight:306.40
IUPAC Name: 2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol
InChIKey: RXIUMAOXORBRCY-UHFFFAOYSA-N
SMILES: OCCNC1C(NC2=C3C=C(C4=CC=CC=C4)C=C2)=C3CCC1
Biological Activity: CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer[1][2].
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CASIN | 99.56% | CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-119098GSK983 -
Similarity Score 0.61
HY-129253GSK984 -
Similarity Score 0.54
HY-1346535-Ph-IAA -
Similarity Score 0.54
HY-184083Fenharmane -
Similarity Score 0.53
HY-148046USP15-IN-1 -
Similarity Score 0.52
HY-116504WB-308 -
Similarity Score 0.52
HY-N18435Komaroidine -
Similarity Score 0.52
HY-120768A-30312 -
Similarity Score 0.51
HY-N2881Antirhine -
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References
- [1]. Florian MC et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell, 2012 May 4, 10(5):520-30. [Content Brief]
- [2]. Nguyen P, et al. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Front Oncol. 2019 Oct 1;9:958. doi: 10.3389/fonc.2019.00958. [Content Brief]
