2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bacterial Reactive Oxygen Species (ROS)
  4. Komaroidine

Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight.

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Komaroidine

Komaroidine Chemical Structure

CAS No. : 6649-76-9

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Komaroidine Related Antibodies

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Description

Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight[1][2].

In Vitro

Komaroidine (compound B2) potently inhibits Xoo, Xac, and Psa with EC50 values of 1.12 μg/mL, 4.85 μg/mL, and 20.08 μg/mL, respectively[1].
Komaroidine (12.5-50.0 μg/mL; 15 h) induces dose-dependent ROS accumulation in Xoo cells, with a 4.1-fold increase at 50.0 μg/mL[1].
Komaroidine (3.125-50.0 μg/mL) disrupts antioxidant enzyme activity in Xoo cells, with complete SOD inactivation and declining CAT activity at concentrations ≥12.5 μg/mL[1].
Komaroidine (25.0 μg/mL) synergistically enhances Xoo sensitivity to 0.05 mM H2O2, completely suppressing bacterial growth[1].
Komaroidine (12.5-50.0 μg/mL; 15 h) induces dose-dependent apoptosis in Xoo cells, with a 56.90% total apoptotic rate at 50.0 μg/mL, and increases membrane permeability in Xoo cells in a dose-dependent manner[1].
Komaroidine (compound B2) (25.0 μg/mL; 15 h) alters the transcriptome of Xoo PXO99A cells, affecting metabolic, stress, and apoptosis-related pathways[1].
Komaroidine (compound B2) (200 μg/mL; pot experiment application) exhibits superior in vivo control efficacy against rice bacterial leaf blight (BLB) by significantly reducing bacterial burden in infected tissues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Komaroidine Related Antibodies
Molecular Weight

214.31

Formula

C14H18N2
CAS No.
SMILES

CCCC(NCC1)C2=C1C3=CC=CC=C3N2
Structure Classification
Initial Source
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Storage

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Purity & Documentation
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Komaroidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Komaroidine6649-76-9BacterialReactive Oxygen Species (ROS)reactive oxygen speciesNitraria komaroviirice bacterial leaf blightphytopathogenic bacteriaNitraria schoberiPseudomonas syringae pv. actinidiaebacterial apoptosisXanthomonas axonopodis pv. citriredox homeostasisXanthomonas oryzae pv. oryzaeInhibitorinhibitorinhibit

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