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Cat. No.: HY-184083

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Fenharmane

Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle.

For research use only. We do not sell to patients.

CAS No.: 3851-30-7
Formula: C₁₈H₁₈N₂
Molecular Weight:262.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fenharmane Chemical Structure

CAS No.: 3851-30-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle^[1].

IC₅₀ & Target^[1]

5HT2B

All 5-HT Receptor Isoforms :

In Vitro

Fenharmane (compound19) exhibits antagonistic activity against 5-HT-induced contractile responses in isolated fundus smooth muscle tissues of rats, with a negative logarithm of the apparent dissociation constant (-log K_B) of 7.61^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3851-30-7
Molecular Weight 262.35
Formula C₁₈H₁₈N₂
SMILES

C1(CC2NCCC3=C2NC4=C3C=CC=C4)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Audia JE, et al. Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. J Med Chem. 1996 Jul 5;39(14):2773-80. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Fenharmane

All 5-HT Receptor Isoforms