1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    GPCR/G Protein
  2. Calcium Channel
    Sodium Channel
    Dopamine Receptor
  3. Flunarizine dihydrochloride

Flunarizine dihydrochloride 

Cat. No.: HY-B0358A Purity: 99.92%
Handling Instructions

Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride, a diphenylpiperazine derivative, has the potential for peripheral vessels dilator and migraine prophylaxis.

For research use only. We do not sell to patients.

Flunarizine dihydrochloride Chemical Structure

Flunarizine dihydrochloride Chemical Structure

CAS No. : 30484-77-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 86 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 86 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 78 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Flunarizine dihydrochloride

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932. 

    Western blot analysis of SUM149PT cells treated by FLN (20 μM, 48 h).

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932. 

    FLN enhances autophagic influx and N-Ras translocation to autophagosomes. Cells co-transfected with mCherry-N-Ras and EGFP-LC3 are imaged by confocal microscopy after FLN treatment.

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932. 

    SUM149PT cells are first treated with FLN as in panel-A, followed by autophagy inhibitors 3-MA (5 mM), chloroquine (20 μM) or bafilomycin A1 (20 nM) for another 24 hours. The proteasome inhibitor MG132 (15 μM) is included as a negative control to show unabated N-Ras reduction. The cells are then harvested and analyzed by Western blot.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride, a diphenylpiperazine derivative, has the potential for peripheral vessels dilator and migraine prophylaxis[1][2][3].

    IC50 & Target[1][3]

    T-type calcium channel

     

    D2 Receptor

     

    In Vitro

    Flunarizine dihydrochloride blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons in a concentration-dependent manner, respectively[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    477.42

    Formula

    C₂₆H₂₈Cl₂F₂N₂

    CAS No.
    SMILES

    FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.Cl.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (104.73 mM; Need ultrasonic)

    H2O : 1 mg/mL (2.09 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0946 mL 10.4730 mL 20.9459 mL
    5 mM 0.4189 mL 2.0946 mL 4.1892 mL
    10 mM 0.2095 mL 1.0473 mL 2.0946 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    FlunarizineCalcium ChannelSodium ChannelDopamine ReceptorCa2+ channelsCa channelsNa channelsNa+ channelsInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Flunarizine dihydrochloride
    Cat. No.:
    HY-B0358A
    Quantity:
    MCE Japan Authorized Agent: