2. Membrane Transporter/Ion Channel
    Neuronal Signaling
    GPCR/G Protein
  3. Calcium Channel
    Sodium Channel
    Dopamine Receptor
  4. Flunarizine dihydrochloride

Flunarizine dihydrochloride 

Cat. No.: HY-B0358A Purity: 99.87%
COA Handling Instructions

Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

For research use only. We do not sell to patients.

Flunarizine dihydrochloride Chemical Structure

Flunarizine dihydrochloride Chemical Structure

CAS No. : 30484-77-6

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Solution
10 mM * 1 mL in DMSO USD 86 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Solid
500 mg USD 78 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Flunarizine dihydrochloride:

Top Publications Citing Use of Products

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932.   [Abstract]

    SUM149PT cells are first treated with FLN as in panel-A, followed by autophagy inhibitors 3-MA (5 mM), chloroquine (20 μM) or bafilomycin A1 (20 nM) for another 24 hours. The proteasome inhibitor MG132 (15 μM) is included as a negative control to show unabated N-Ras reduction. The cells are then harvested and analyzed by Western blot.

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932.   [Abstract]

    Western blot analysis of SUM149PT cells treated by FLN (20 μM, 48 h).

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932.   [Abstract]

    FLN enhances autophagic influx and N-Ras translocation to autophagosomes. Cells co-transfected with mCherry-N-Ras and EGFP-LC3 are imaged by confocal microscopy after FLN treatment.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5].

    IC50 & Target[1][3]

    T-type calcium channel

     

    D2 Receptor

     

    In Vitro

    Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively[2].
    Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells[4].
    Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[4]

    Cell Line: Chromaffin cells
    Concentration: 10 and 30 μM
    Incubation Time: 24 hours
    Result: Showed a tendency to increase cell death at the concentration of 10 μM, and showed near 100% cell loss at the concentration of 30 μM.
    In Vivo

    Flunarizine (intraperitoneal injection; 30 mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide[5]
    Dosage: 30 mg/kg
    Administration: Intraperitoneal injection; 30 mg/kg; once
    Result: Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release.
    Inhibited the pulmonary inflammation.
    Clinical Trial
    Molecular Weight

    477.42

    Appearance

    Solid

    Formula

    C26H28Cl2F2N2
    CAS No.
    SMILES

    FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.Cl.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (104.73 mM; Need ultrasonic)

    H2O : 1 mg/mL (2.09 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0946 mL 10.4730 mL 20.9459 mL
    5 mM 0.4189 mL 2.0946 mL 4.1892 mL
    10 mM 0.2095 mL 1.0473 mL 2.0946 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (20.95 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Flunarizine30484-77-6Calcium ChannelSodium ChannelDopamine ReceptorCa2+ channelsCa channelsNa channelsNa+ channelsanticonvulsive activityantimigraine activityperipheral vasodilator effectchromaffin cellcultured rat cortical neuronsInhibitorinhibitorinhibit

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    Product Name:
    Flunarizine dihydrochloride
    Cat. No.:
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