1. Membrane Transporter/Ion Channel
  2. Calcium Channel
  3. Flunarizine dihydrochloride

Flunarizine dihydrochloride 

Cat. No.: HY-B0358A Purity: 99.76%
Handling Instructions

Flunarizine is a selective calcium entry blocker.

For research use only. We do not sell to patients.

Flunarizine dihydrochloride Chemical Structure

Flunarizine dihydrochloride Chemical Structure

CAS No. : 30484-77-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 86 In-stock
Estimated Time of Arrival: December 31
500 mg USD 78 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Top Publications Citing Use of Products

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932. 

    Western blot analysis of SUM149PT cells treated by FLN (20 μM, 48 h).

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932. 

    FLN enhances autophagic influx and N-Ras translocation to autophagosomes. Cells co-transfected with mCherry-N-Ras and EGFP-LC3 are imaged by confocal microscopy after FLN treatment.

    Flunarizine dihydrochloride purchased from MCE. Usage Cited in: Sci Rep. 2018 Nov 16;8(1):16932. 

    SUM149PT cells are first treated with FLN as in panel-A, followed by autophagy inhibitors 3-MA (5 mM), chloroquine (20 μM) or bafilomycin A1 (20 nM) for another 24 hours. The proteasome inhibitor MG132 (15 μM) is included as a negative control to show unabated N-Ras reduction. The cells are then harvested and analyzed by Western blot.
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    Description

    Flunarizine is a selective calcium entry blocker. Target: Calcium Channel Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (RDP). From Wikipedia.

    Clinical Trial
    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (104.73 mM; Need ultrasonic)

    H2O : 1 mg/mL (2.09 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0946 mL 10.4730 mL 20.9459 mL
    5 mM 0.4189 mL 2.0946 mL 4.1892 mL
    10 mM 0.2095 mL 1.0473 mL 2.0946 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution

    References
    Molecular Weight

    477.42

    Formula

    C₂₆H₂₈Cl₂F₂N₂

    CAS No.

    30484-77-6

    SMILES

    FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.Cl.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Flunarizine dihydrochloride
    Cat. No.:
    HY-B0358A
    Quantity:

    Flunarizine dihydrochloride

    Cat. No.: HY-B0358A